Enzymatic method for inactivation of aminoglycosides during measurement of postantibiotic effect

被引：11

作者：

DenHollander, JG ^{[1
]}

Mouton, JW ^{[1
]}

BakkerWoudenberg, IAJM ^{[1
]}

Vleggaar, FP ^{[1
]}

VanGoor, MPJ ^{[1
]}

Verbrugh, HA ^{[1
]}

机构：

[1] ERASMUS UNIV ROTTERDAM,DEPT CLIN MICROBIOL & ANTIMICROBIAL THERAPY,3015 GD ROTTERDAM,NETHERLANDS

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1996年 / 40卷 / 02期

关键词：

D O I：

10.1128/AAC.40.2.488

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

To determine the postantibiotic effect of aminoglycosides, two methods are currently being used to remove the test drug: repeated mashing and dilution. An enzymatic inactivation method of removing gentamicin and tobramycin was developed and compared with the dilution method. This enzymatic method provides a rapid and simple alternative method of removing aminoglycosides which results in reliable postantibiotic-effect values.

引用

页码：488 / 490

页数：3

共 12 条

[1] [Anonymous], 1990, METHODS DILUTION ANT
[2] CARLBERG DM, 1985, ANTIBIOTICS LABORATO, P64
[3] Craig WA, 1986, ANTIBIOTICS LABORATO, P515
[4] IMPACT OF PH AND CATIONIC SUPPLEMENTATION ON INVITRO POSTANTIBIOTIC EFFECT
GUDMUNDSSON, A
ERLENDSDOTTIR, H
GOTTFREDSSON, M
GUDMUNDSSON, S
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1991, 35 (12) : 2617 - 2624
[5] POSTANTIBIOTIC EFFECT OF AMINOGLYCOSIDES ON GRAM-NEGATIVE BACTERIA EVALUATED BY A NEW METHOD
ISAKSSON, B
NILSSON, L
MALLER, R
SOREN, L
[J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1988, 22 (01) : 23 - 33
[6] POSTANTIBIOTIC EFFECT OF AMINOGLYCOSIDES ON STAPHYLOCOCCI
ISAKSSON, B
MALLER, R
NILSSON, LE
NILSSON, M
[J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1993, 32 (02) : 215 - 222
[7] LEITNER F, 1982, AMINOGLYCOSIDES MICR, P29
[8] THE POSTANTIBIOTIC EFFECT
MACKENZIE, FM
GOULD, IM
[J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1993, 32 (04) : 519 - 537
[9] THE ACTION OF PENICILLIN ON STAPHYLOCOCCUS
PARKER, RF
MARSH, HC
[J]. JOURNAL OF BACTERIOLOGY, 1946, 51 (02) : 181 - 186
[10] ROOSENDAAL R, 1992, IMPACT ANTIBIOTIC DO, P5

← 1 2 →