Live birth after polar body array comparative genomic hybridization prediction of embryo ploidy-the future of IVF?

被引：61

作者：

Fishel, Simon ^{[1
]}

Gordon, Anthony ^{[2
]}

Lynch, Colleen ^{[1
]}

Dowell, Ken ^{[1
]}

Ndukwe, George ^{[1
]}

Kelada, Ehab ^{[1
]}

Thornton, Simon ^{[1
]}

Jenner, Lucy ^{[1
]}

Cater, Ellen ^{[1
]}

Brown, Anthony ^{[1
]}

Garcia-Bernardo, Jose ^{[1
]}

机构：

[1] CARE Fertil, Nottingham NG8 6PZ, England

[2] BlueGnome Ltd, Cambridge, England

来源：

FERTILITY AND STERILITY | 2010年 / 93卷 / 03期

关键词：

IVF; polar body biopsy; PGS; PGD; array CGH; egg chromosomes; birth; PREIMPLANTATION GENETIC DIAGNOSIS; IN-VITRO FERTILIZATION; COPY NUMBER; ANEUPLOIDY; CGH;

D O I：

10.1016/j.fertnstert.2009.09.055

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objective: To ascertain meiotic aneuploidy of the human egg using array comparative genomic hybridization to evaluate the 23-paired chromosome copy number of first polar body as an objective prognosticator of embryo viability for embryo transfer in the same cycle. Design: Case report. Setting: Independent-sector IVF program. Patient(s): A 41-year-old woman with a history of 13 failed cycles of IVF. Intervention(s): Polar body biopsy of metaphase II eggs. Main Outcome Measure(s): Birth. Result(s): Two of the nine eggs were euploid, and the resulting embryos, although morphologically inferior to sibling embryos, were selected for transfer to the uterus, resulting in the birth of a normal healthy baby. Conclusion(s): Selection of euploid eggs, as an objective parameter of subsequent embryo viability and with the opportunity to transfer embryos in the same cycle could maximise the opportunity for live birth after IVF even in cases with poor prognosis. (Fertil Steril (R) 2010; 93: 1006.e7-e10. (C) 2010 by American Society for Reproductive Medicine.)

引用

页码：1006.e7 / 1006.e10

页数：4

共 20 条

[1] Enhanced detection of clinically relevant genomic imbalances using a targeted plus whole genome oligonucleotide microarray [J].