The Amnestic Syndrome of Hippocampal type in Alzheimer's Disease: An MRI Study

被引：124

作者：

Sarazin, Marie ^{[1
,2
]}

Chauvire, Valerie ^{[2
]}

Gerardin, Emilie ^{[3
]}

Colliot, Olivier ^{[3
]}

Kinkingnehun, Serge ^{[2
]}

de Souza, Leonardo Cruz ^{[1
,2
]}

Hugonot-Diener, Laurence ^{[2
]}

Garnero, Line ^{[3
]}

Lehericya, Stephane ^{[2
,4
]}

Chupin, Marie ^{[3
]}

Dubois, Bruno ^{[1
,2
]}

机构：

[1] Hop La Pitie Salpetriere, Res & Resource Memory Ctr, F-75013 Paris, France

[2] Hop La Pitie Salpetriere, CRICM UPMC, INSERM, UMR 975, F-75013 Paris, France

[3] UPMC Univ Paris, CNRS UPR LENA 640, Cognit Neurosci & Brain Imaging Lab, Paris, France

[4] Univ Paris 06, Hop La Pitie Salpetriere, CENIR, Paris, France

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2010年 / 22卷 / 01期

关键词：

Alzheimer's disease; assessment of cognitive disorders/dementia; cognitive neuropsychology in dementia; memory; MRI; MILD COGNITIVE IMPAIRMENT; VOXEL-BASED MORPHOMETRY; MEMORY IMPAIRMENT; EPISODIC MEMORY; FRONTOTEMPORAL DEMENTIA; AUTOMATED SEGMENTATION; MATTER LOSS; ATROPHY; DIAGNOSIS; DEFICITS;

D O I：

10.3233/JAD-2010-091150

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The Free and Cued Selective Reminding Test (FCSRT) is a verbal episodic memory test used to identify patients with mild Alzheimer's disease (AD). The present study investigates the relationships between performance on FCSRT and grey matter atrophy assessed with structural MRI in patients with AD. Three complementary MRI-based analyses (VBM analysis, ROI-based analysis, and three-dimensional hippocampal surface-based shape analysis) were performed in 35 patients with AD to analyze correlations between regional atrophy and their scores for episodic memory using the FCSRT. With VBM analysis, the total score on the FCSRT was correlated with left medial temporal lobe atrophy including the left hippocampus but also the thalami. In addition, using ROI-based analysis, the total recall score on the FCSRT was correlated with the left hippocampal volume. With three-dimensional hippocampal surface-based shape analysis, both free recall and total recall scores were correlated with regions corresponding approximately to the CA1 field. No correlation was found with short term memory scores using any of these methods of analysis. In AD, the FCSRT may be considered as a useful clinical marker of memory disorders due to medial temporal damage, specially the CA1 field of the hippocampus.

引用

页码：285 / 294

页数：10

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