Design and development of polymers for gene delivery

被引：2170

作者：

Pack, DW

Hoffman, AS

Pun, S

Stayton, PS

机构：

[1] Univ Illinois, Dept Chem & Biomol Engn, Urbana, IL 61801 USA

[2] Univ Washington, Dept Bioengn, Seattle, WA 98195 USA

来源：

NATURE REVIEWS DRUG DISCOVERY | 2005年 / 4卷 / 07期

关键词：

D O I：

10.1038/nrd1775

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The lack of safe and efficient gene-delivery methods is a limiting obstacle to human gene therapy. Synthetic gene-delivery agents, although safer than recombinant viruses, generally do not possess the required efficacy. In recent years, a variety of effective polymers have been designed specifically for gene delivery, and much has been learned about their structure-function relationships. With the growing understanding of polymer gene-delivery mechanisms and continued efforts of creative polymer chemists, it is likely that polymer-based gene-delivery systems will become an important tool for human gene therapy.

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页码：581 / 593

页数：13

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