Keratinocyte growth factor as mediator of mesenchymal-epithelial interactions in the development of androgen target organs

被引：11

作者：

Cunha, GR ^{[1
]}

Foster, BA ^{[1
]}

Sugimura, Y ^{[1
]}

Hom, YK ^{[1
]}

机构：

[1] MIE UNIV, DEPT UROL, TSU, MIE 514, JAPAN

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 1996年 / 7卷 / 02期

关键词：

androgens; ducted gland morphogenesis; epithelial growth; keratinocyte growth factor (KGF; FGF-7); prostate development; testosterone;

D O I：

10.1006/scdb.1996.0027

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Ductal branching morphogenesis in the prostate gland is elicited by androgens via mesenchymal-epithelial interactions mediated by paracrine influences from mesenchyme. Keratinocyte growth factor (KGF) was investigated as a potential paracrine mediator by examining neonatal rat ventral prostates (VP's) cultured under serum-free conditions. In the presence of testosterone (10(-8) M), VP's grew and underwent ductal branching morphogenesis. Neutralization of endogenous KGF with a monoclonal antibody to KGF inhibited androgen-stimulated VP growth and ductal branching morphogenesis. When exogenous KGF was added to basal medium in the absence of testosterone, VP growth and ductal branching morphogenesis was stimulated. Transcripts for KGF and KGF receptor were detected in neonatal VPs. These data suggest that KGF may play an important role as a mesenchymal paracrine mediator of androgen-induced epithelial growth and ductal branching morphogenesis. (C) 1996 Academic Press Ltd

引用

页码：203 / 210

页数：8

共 44 条

[1] KERATINOCYTE GROWTH-FACTOR - A FIBROBLAST GROWTH-FACTOR FAMILY MEMBER WITH UNUSUAL TARGET-CELL SPECIFICITY [J].