Clinical Applications for Biomarkers of Acute and Chronic Graft-versus-Host Disease

被引：45

作者：

Levine, John E. ^{[1
]}

Paczesny, Sophie

Sarantopoulos, Stefanie ^{[2
,3
]}

机构：

[1] Univ Michigan, Ctr Comprehens Canc, Blood & Marrow Transplantat Program, Ann Arbor, MI 48109 USA

[2] Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA

[3] Univ N Carolina, Sch Med, Chapel Hill, NC USA

来源：

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION | 2012年 / 18卷 / 01期

关键词：

Acute GVHD; Chronic GVHD; Biomarkers; Allogeneic hematopoietic cell transplantation; BONE-MARROW-TRANSPLANTATION; STEM-CELL TRANSPLANTATION; SERUM CYTOKINE LEVELS; NECROSIS-FACTOR-ALPHA; CONSENSUS DEVELOPMENT PROJECT; C-REACTIVE PROTEIN; B-CELL; PROGNOSTIC MARKER; ACTIVATING FACTOR; CHRONIC GVHD;

D O I：

10.1016/j.bbmt.2011.10.019

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Acute and chronic graft-versus-host disease (aGVHD, cGVHD) are serious complications of allogeneic hematopoietic cell transplantation. The complex pathophysiology of these disease processes is associated with immune system activation, the release of cytokines and chemokines, and alterations in cell populations. The blood levels of specific protein and cellular levels in patients with GVHD have correlated with the development, diagnosis, and prognosis of GVHD. Here, we review the most promising biomarkers for aGVHD and cGVHD with clinical relevance. The utility of GVHD biomarkers in clinical care of allogeneic hematopoietic cell transplantation recipients needs to be proven through clinical trials, and potential approaches to trial design are discussed. Biol Blood Marrow Transplant 18: S116-S124 (2012) (C) 2012 American Society for Blood and Marrow Transplantation

引用

收藏

页码：S116 / S124

页数：9

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