Transforming growth factor beta-1 gene polymorphism and bone mineral density in Japanese adolescents

被引：42

作者：

Yamada, Y

Hosoi, T

Makimoto, F

Tanaka, H

Seino, Y

Ikeda, K

机构：

[1] Natl Inst Longev Sci, Dept Geriatr Res, Aichi 4748522, Japan

[2] Tokyo Metropolitan Geriatr Hosp, Endocrinol Sect, Tokyo 173, Japan

[3] Akiyama Mem Hosp, Dept Obstet & Gynecol, Hakodate, Hokkaido, Japan

[4] Okayama Univ, Sch Med, Dept Pediat, Okayama 700, Japan

来源：

AMERICAN JOURNAL OF MEDICINE | 1999年 / 106卷 / 04期

关键词：

D O I：

10.1016/S0002-9343(99)00043-1

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Transforming growth factor (TGF)-β1 stimulates the proliferation and differentiation of osteoblasts. A polymorphism of the TGF-β1 gene was associated with bone mineral density in Japanese adolescents.

引用

页码：477 / 479

页数：3

共 14 条

[1]

Bonewald L. F., 1996, P647

[2] Polymorphisms of the transforming growth factor-beta 1 gene in relation to myocardial infarction and blood pressure - The Etude Cas-Temoin de l'Infarctus du Myocarde (ECTIM) Study [J].

Cambien, F ;

Ricard, S ;

Troesch, A ;

Mallet, C ;

Generenaz, L ;

Evans, A ;

Arveiler, D ;

Luc, G ;

Ruidavets, JB ;

Poirier, O .

HYPERTENSION, 1996, 28 (05) :881-887

[3] INTRON-EXON STRUCTURE OF THE HUMAN TRANSFORMING GROWTH-FACTOR-BETA PRECURSOR GENE [J].

DERYNCK, R ;

RHEE, L ;

CHEN, EY ;

VANTILBURG, A .

NUCLEIC ACIDS RESEARCH, 1987, 15 (07) :3188-3189

[4] Reduced bone density and osteoporosis associated with a polymorphic Sp1 binding site in the collagen type I alpha 1 gene [J].

Grant, SFA ;

Reid, DM ;

Blake, G ;

Herd, R ;

Fogelman, I ;

Ralston, SH .

NATURE GENETICS, 1996, 14 (02) :203-205

[5] The vitamin D receptor start codon polymorphism (FokI) and bone mineral density in premenopausal American black and white women [J].

Harris, SS ;

Eccleshall, TR ;

Gross, C ;

DawsonHughes, B ;

Feldman, D .

JOURNAL OF BONE AND MINERAL RESEARCH, 1997, 12 (07) :1043-1048

[6] Estrogen promotes apoptosis of murine osteoclasts mediated by TGF-beta [J].

Hughes, DE ;

Dai, AH ;

Tiffee, JC ;

Li, HH ;

Mundy, GR ;

Boyce, BF .

NATURE MEDICINE, 1996, 2 (10) :1132-1136

[7]

Kobayashi S, 1996, J BONE MINER RES, V11, P306

[8] A sequence variation: 713-8delC in the transforming growth factor-beta 1 gene has higher prevalence in osteoporotic women than in normal women and is associated with very low bone mass in osteoporotic women and increased bone turnover in both osteoporotic and normal women [J].

Langdahl, BL ;

Knudsen, JY ;

Jensen, HK ;

Gregersen, N ;

Eriksen, EF .

BONE, 1997, 20 (03) :289-294

[9] PREDICTION OF BONE-DENSITY FROM VITAMIN-D RECEPTOR ALLELES [J].

MORRISON, NA ;

QI, JC ;

TOKITA, A ;

KELLY, PJ ;

CROFTS, L ;

NGUYEN, TV ;

SAMBROOK, PN ;

EISMAN, JA .

NATURE, 1994, 367 (6460) :284-287

[10] GENETIC-DETERMINANTS OF BONE MASS IN ADULTS - A TWIN STUDY [J].

POCOCK, NA ;

EISMAN, JA ;

HOPPER, JL ;

YEATES, MG ;

SAMBROOK, PN ;

EBERL, S .

JOURNAL OF CLINICAL INVESTIGATION, 1987, 80 (03) :706-710

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