Bacterial outer membrane vesicles and the host-pathogen interaction

被引：682

作者：

Kuehn, MJ ^{[1
]}

Kesty, NC ^{[1
]}

机构：

[1] Duke Univ, Med Ctr, Dept Biochem, Durham, NC 27710 USA

来源：

GENES & DEVELOPMENT | 2005年 / 19卷 / 22期

关键词：

secretion pathway; vesicles; blebs; outer membrane; virulence factors;

D O I：

10.1101/gad.1299905

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Extracellular secretion of products is the major mechanism by which Gram-negative pathogens communicate with and intoxicate host cells. Vesicles released from the envelope of growing bacteria serve as secretory vehicles for proteins and lipids of Gram-negative bacteria. Vesicle production occurs in infected tissues and is influenced by environmental factors. Vesicles play roles in establishing a colonization niche, carrying and transmitting virulence factors into host cells, and modulating host defense and response. Vesicle-mediated toxin delivery is a potent virulence mechanism exhibited by diverse Gram-negative pathogens. The biochemical and functional properties of pathogen-derived vesicles reveal their potential to critically impact disease.

引用

页码：2645 / 2655

页数：11

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