Tetraspanins: Interactions and interplay with integrins

被引：96

作者：

Bassani, Silvia ^{[2
]}

Cingolani, Lorenzo A. ^{[1
,3
,4
]}

机构：

[1] Italian Inst Technol, Dept Neurosci & Brain Technol, I-16163 Genoa, Italy

[2] Univ Milan, CNR Inst Neurosci Cellular & Mol Pharmacol, Dept Pharmacol, I-20122 Milan, Italy

[3] UCL, MRC Lab Mol Cell Biol, London WC1E 6BT, England

[4] UCL, Cell Biol Unit, London WC1E 6BT, England

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2012年 / 44卷 / 05期

基金：

英国医学研究理事会;

关键词：

Tetraspanin; Integrin; PSD domain protein; X-linked mental retardation; Brain; LINKED MENTAL-RETARDATION; ALPHA-3-BETA-1; INTEGRIN; NEURITE OUTGROWTH; CELL-MIGRATION; TM4SF PROTEIN; CD151; COMPLEXES; CD81; METASTASIS; ASSOCIATE;

D O I：

10.1016/j.biocel.2012.01.020

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Tetraspanins are small transmembrane proteins present on the cell surface of almost every eukaryotic cell. Through binding with other transmembrane and intracellular proteins, they regulate diverse cellular processes ranging from cell adhesion and motility to synapse formation and tumor progression. Here, we provide a brief overview of molecular, cellular and clinical studies to illustrate how the multiple functions of this fascinating family of molecules stem from their interplay with multiple molecular partners. In particular, we emphasize the special relationship between tetraspanins and the cell adhesion molecules integrins in regulating cell physiology in health and disease. (c) 2012 Elsevier Ltd. All rights reserved.

引用

页码：703 / 708

页数：6

共 59 条

[1]

A novel 2 bp deletion in the TM4SF2 gene is associated with MRX58 [J].