Gene expression profiles in normal and Otx2-/- early gastrulating mouse embryos

被引：51

作者：

Zakin, L

Reversade, B

Virlon, B

Rusniok, C

Glaser, P

Elalouf, JM

Brûlet, P

机构：

[1] CNRS, URA 1947, Unite Embryol Mol, F-75724 Paris 15, France

[2] Inst Pasteur, Lab enom Microorganismes Pathogenes, F-75724 Paris 15, France

[3] CEA Saclay, CNRS,URA 1859, Serv Biol Cellulaire, Dept Biol Cellulaire & Mol, F-91191 Gif Sur Yvette, France

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2000年 / 97卷 / 26期

关键词：

D O I：

10.1073/pnas.011513398

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The mouse Otx2 gene is a homeobox transcription factor required as early as gastrulation for the proper development of the head. We compared gene expression profiles in wild-type and Otx2(-/-) 6.5 days postcoitum embryos by using a serial analysis of gene expression assay adapted to microdissected structures. Among a broader list, the study of six genes found to be differentially expressed allows defining a role for Otx2 in the orchestration of cell movements leading to the adequate organization of the embryo before gastrulation.

引用

页码：14388 / 14393

页数：6

共 26 条

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