The (Pro)Renin receptor and the kidney

被引：47

作者：

Ichihara, Atsuhiro ^{[1
]}

Kaneshiro, Faha Yuki ^{[1
]}

Takemitsu, Tomoko ^{[1
]}

Sakodo, Moriyo ^{[1
]}

Itoh, Hiroshi ^{[1
]}

机构：

[1] Keio Univ, Sch Med, Shinjuku Ku, Tokyo, Japan

来源：

SEMINARS IN NEPHROLOGY | 2007年 / 27卷 / 05期

关键词：

angiotensin; mesangium; nonproteolytic activation; podocytes; prorenin;

D O I：

10.1016/j.semnephrol.2007.07.005

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Prorenin binding to the (pro)renin receptor not only causes a nonproteolytic activation of prorenin leading to the activation of the renin-angiotensin system (RAS), but also stimulates the receptor's own intracellular signaling pathways independent of the RAS. Within the kidneys, the (pro)renin receptor is present in the glomerular mesangium and podocytes, which play an important role in the maintenance of the glomerular filtration barrier. Therefore, prorenin-receptor blockers, which competitively bind to the receptor as a decoy peptide, have superior benefits with regard to proteinuria and glomerulosclerosis in experimental animal models with elevated plasma prorenin levels such as diabetes and hypertension compared with conventional RAS inhibitors, possibly by inhibiting both the nonproteolytic activation of prorenin and RAS-independent intracellular signals. © 2007 Elsevier Inc. All rights reserved.

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页码：524 / 528

页数：5

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