Estrogen-Related Receptor α: A Significant Regulator and Promising Target in Bone Homeostasis and Bone Metastasis

被引：22

作者：

Feng, Chun ^{[1
]}

Xu, Zhaowei ^{[1
]}

Tang, Xiaojie ^{[2
]}

Cao, Haifei ^{[2
]}

Zhang, Guilong ^{[1
]}

Tan, Jiangwei ^{[2
]}

机构：

[1] Binzhou Med Univ, Shandong Technol Innovat Ctr Mol Targeting & Inte, Sch Pharm, Yantai 264003, Peoples R China

[2] Binzhou Med Univ, Dept Spinal Surg, Yantai Affiliated Hosp, Yantai 264100, Peoples R China

来源：

MOLECULES | 2022年 / 27卷 / 13期

基金：

中国国家自然科学基金;

关键词：

ERR alpha; bone; osteoclast; osteoblast; bone metastasis; ERR-ALPHA; BREAST-CANCER; OSTEOBLAST DIFFERENTIATION; OSTEOGENIC DIFFERENTIATION; GENE-EXPRESSION; ORPHAN; ACTIVATION; GAMMA; CELLS; OSTEOCLASTOGENESIS;

D O I：

10.3390/molecules27133976

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Bone homeostasis is maintained with the balance between bone formation and bone resorption, which is involved in the functional performance of osteoblast and osteoclast. Disruption of this equilibrium usually causes bone disorders including osteoporosis, osteoarthritis, and osteosclerosis. In addition, aberrant activity of bone also contributes to the bone metastasis that frequently occurs in the late stage of aggressive cancers. Orphan nuclear receptor estrogen-related receptor (ERR alpha) has been demonstrated to control the bone cell fate and the progression of tumor cells in bone through crosstalk with various molecules and signaling pathways. However, the defined function of this receptor in bone is inconsistent and controversial. Therefore, we summarized the latest research and conducted an overview to reveal the regulatory effect of ERR alpha on bone homeostasis and bone metastasis, this review may broaden the present understanding of the cellular and molecular model of ERR alpha and highlight its potential implication in clinical therapy.

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页数：11

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