Two antiviral compounds from the plant Stylogne cauliflora as inhibitors of HCVNS3 protease

被引：36

作者：

Hegde, VR ^{[1
]}

Pu, HY ^{[1
]}

Patel, M ^{[1
]}

Das, PR ^{[1
]}

Butkiewicz, N ^{[1
]}

Arreaza, G ^{[1
]}

Gullo, VP ^{[1
]}

Chan, TM ^{[1
]}

机构：

[1] Schering Plough Res Inst, Kenilworth, NJ 07033 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 17期

关键词：

D O I：

10.1016/S0960-894X(03)00584-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

The 70% aq ruethanolic extract of the Peruvian plant Stylogne caul flora was found to contain two novel oligophenolic compounds SCH 644343 (1) and SCH 644342 (2), which were identified as inhibitors of HCV NS3 protease. The structure of I and 2 was established based on high-resolution NMR studies. Compound 1 inhibited HCV NS3 protease with an IC50 of 0.3 muM, while compound 2 showed an IC50 of 0-8 muM. (C) 2003 Elsevier Ltd. All rights reserved.

引用

收藏

页码：2925 / 2928

页数：4

相关论文

共 14 条

[1]

Recovery, persistence, and sequelae in hepatitis C virus infection: A perspective on long-term outcome [J].

Alter, HJ ;

Seeff, LB .

SEMINARS IN LIVER DISEASE, 2000, 20 (01) :17-35

[2]

TANNINS IN BLACK PLUM SEEDS [J].

BHATIA, IS ;

BAJAJ, KL ;

GHANGAS, GS .

PHYTOCHEMISTRY, 1971, 10 (01) :219-+

[3]

Blight KJ, 1998, THERAPIES FOR VIRAL HEPATITIS, P207

[4]

Routes of infection, viremia, and liver disease in blood donors found to have hepatitis C virus infection [J].

ConryCantilena, C ;

VanRaden, M ;

Gibble, J ;

Melpolder, J ;

Shakil, AO ;

Viladomiu, L ;

Cheung, L ;

DiBisceglie, A ;

Hoofnagle, J ;

Shih, JW ;

Kaslow, R ;

Ness, P ;

Alter, HJ .

NEW ENGLAND JOURNAL OF MEDICINE, 1996, 334 (26) :1691-1696

[5]

HEPATITIS-C - PROGRESS AND PROBLEMS [J].

CUTHBERT, JA .

CLINICAL MICROBIOLOGY REVIEWS, 1994, 7 (04) :505-&

[6]

3-0-METHYLKAEMPFEROL AND 3-0-METHYLGALANGIN IN OIL COMPONENT OF POPULUS NIGRA BUDS [J].

EGGER, K ;

TISSUT, M ;

WOLLENWEBER, E .

PHYTOCHEMISTRY, 1969, 8 (12) :2425-+

[7]

Two tannins from Phyllanthus tenellus [J].

Huang, YL ;

Chen, CC ;

Hsu, FL ;

Chen, CF .

JOURNAL OF NATURAL PRODUCTS, 1998, 61 (04) :523-524

[8]

KIM JL, 1997, CELL, V89, P159

[9]

The crystal structure of hepatitis C virus NS3 proteinase reveals a trypsin-like fold and a structural zinc binding site [J].

Love, RA ;

Parge, HE ;

Wickersham, JA ;

Hostomsky, Z ;

Habuka, N ;

Moomaw, EW ;

Adachi, T ;

Hostomska, Z .

CELL, 1996, 87 (02) :331-342

[10]

Thonningianins A and B, new antioxidants from the African medicinal herb Thonningia sanguinea [J].

Ohtani, II ;

Gotoh, N ;

Tanaka, J ;

Higa, T ;

Gyamfi, MA ;

Aniya, Y .

JOURNAL OF NATURAL PRODUCTS, 2000, 63 (05) :676-679