Age at onset of multiple sclerosis is correlated to use of combined oral contraceptives and childbirth before diagnosis

被引：62

作者：

Holmqvist, Per ^{[1
,2
]}

Hammar, Mats ^{[2
]}

Landtblom, Anne-Marie ^{[3
]}

Brynhildsen, Jan ^{[2
]}

机构：

[1] Cty Hosp, Clin Dept Obstet & Gynecol, SE-85186 Sundsvall, Sweden

[2] Linkoping Univ, Fac Hlth Sci, Dept Clin & Expt Med, Div Womens & Childrens Hlth, Linkoping, Sweden

[3] Linkoping Univ, Fac Hlth Sci, Dept Clin & Expt Med, Div Neurol, Linkoping, Sweden

来源：

FERTILITY AND STERILITY | 2010年 / 94卷 / 07期

关键词：

Multiple sclerosis; estrogen; combined oral contraceptives; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; TNF-ALPHA; PREGNANCY; ESTROGEN; ESTRIOL; DISEASE; MICE; RECRUITMENT; POSTPARTUM; PATTERNS;

D O I：

10.1016/j.fertnstert.2010.06.045

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

The aim of this study was to evaluate whether age of onset of multiple sclerosis is related to use of combined oral contraceptives and/or timing of childbirth. The results showed that use of combined oral contraceptives and childbirth before the first multiple sclerosis symptom was correlated to a higher mean age at the onset of the disease. (Fertil Steril (R) 2010;94:2835-7. (C) 2010 by American Society for Reproductive Medicine.)

引用

页码：2835 / 2837

页数：3

共 30 条

[1] Recent use of oral contraceptives and the risk of multiple sclerosis [J].

Alonso, A ;

Jick, SS ;

Olek, MJ ;

Ascherio, A ;

Jick, H ;

Hernán, MA .

ARCHIVES OF NEUROLOGY, 2005, 62 (09) :1362-1365

[2] Correlation between sex hormones and magnetic resonance imaging lesions in multiple sclerosis [J].

Bansil, S ;

Lee, HJ ;

Jindal, S ;

Holtz, CR ;

Cook, SD .

ACTA NEUROLOGICA SCANDINAVICA, 1999, 99 (02) :91-94

[3] THE INFLUENCE OF PREGNANCY ON RELAPSES IN MULTIPLE-SCLEROSIS - A COHORT STUDY [J].

BERNARDI, S ;

GRASSO, MG ;

BERTOLLINI, R ;

ORZI, F ;

FIESCHI, C .

ACTA NEUROLOGICA SCANDINAVICA, 1991, 84 (05) :403-406

[4] Rate of pregnancy-related relapse in multiple sclerosis [J].

Confavreux, C ;

Hutchinson, M ;

Hours, MM ;

Cortinovis-Tourniaire, P ;

Moreau, T .

NEW ENGLAND JOURNAL OF MEDICINE, 1998, 339 (05) :285-291

[5]

CORREALE J, 1995, J IMMUNOL, V154, P2959

[6] Long-term effects of childbirth in MS [J].

D'hooghe, M. B. ;

Nagels, G. ;

Uitdehaag, B. M. J. .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2010, 81 (01) :38-41

[7]

Damek DM, 1997, MAYO CLIN PROC, V72, P977

[8]

DUQUETTE P, 1993, CURR OPIN NEUROL NEU, V6, P195

[9] IL-12, TNF-α, and hormonal changes during late pregnancy and early postpartum:: Implications for autoimmune disease activity during these times [J].

Elenkov, IJ ;

Wilder, RL ;

Bakalov, VK ;

Link, AA ;

Dimitrov, MA ;

Fisher, S ;

Crane, M ;

Kanik, KS ;

Chrousos, GP .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2001, 86 (10) :4933-4938

[10] IMMUNOLOGICAL RESPONSE IN PREGNANCY - ITS ROLE IN ENDOCRINE DISORDERS OF PREGNANCY AND INFLUENCE ON THE COURSE OF MATERNAL AUTOIMMUNE-DISEASES [J].

FORMBY, B .

ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA, 1995, 24 (01) :187-205

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