Cellular functions of phosphatidylinositol 3-phosphate and FYVE domain proteins

被引：182

作者：

Gillooly, DJ ^{[1
]}

Simonsen, A ^{[1
]}

Stenmark, H ^{[1
]}

机构：

[1] Norwegian Radium Hosp, Dept Biochem, N-0310 Oslo, Norway

来源：

BIOCHEMICAL JOURNAL | 2001年 / 355卷

关键词：

membrane traffic; phosphoinositide; 3-kinase; protein domains; recruitment;

D O I：

10.1042/0264-6021:3550249

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

PtdIns3P is a phosphoinositide 3-kinase product that has been strongly implicated in regulating membrane trafficking in both mammalian and yeast cells. PtdIns3P has been shown to be specifically located on membranes associated with the endocytic pathway. Proteins that contain FYVE zinc-finger domains are recruited to PtdIns3P-containing membranes, Structural information is now available concerning the interaction between FYVE domains and PtdIns3P, A number of proteins have been identified which contain a FYVE domain, and in this review we discuss the functions of PtdIns3P and its FYVE-domain-containing effector proteins in membrane trafficking, cytoskeletal regulation and receptor signalling.

引用

页码：249 / 258

页数：10

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