Protection of mice against fatal pneumococcal challenge by immunization with pneumococcal surface adhesin A (PsaA)

被引：110

作者：

Talkington, DF ^{[1
]}

Brown, BG ^{[1
]}

Tharpe, JA ^{[1
]}

Koenig, A ^{[1
]}

Russell, H ^{[1
]}

机构：

[1] CTR DIS CONTROL & PREVENT,NATL CTR INFECT DIS,SCI RESOURCES PROGRAM,ATLANTA,GA 30333

来源：

MICROBIAL PATHOGENESIS | 1996年 / 21卷 / 01期

关键词：

Streptococcus pneumoniae; surface protein; vaccine;

D O I：

10.1006/mpat.1996.0038

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Pneumococcal surface adhesin A (PsaA) is a 37-kDa surface protein present on Streptococcus pneumoniae having significant homology with fimbrial adhesion proteins. Immunization of CBA/CaHNJXid mice with PsaA using either complete Freund's or TiterMax(TM) adjuvants significantly protected mice against heterologous intravenous challenge with type 3 pneumococcal strain WU2 at doses up to 45 times the LD(50). The results indicate that PsaA warrants further evaluation as a vaccine candidate for human pneumococcal disease.

引用

页码：17 / 22

页数：6

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