Active and selective transcytosis of cell-free human immunodeficiency virus through a tight polarized monolayer of human endometrial cells

被引：59

作者：

Hocini, H

Becquart, P

Bouhlal, H

Chomont, N

Ancuta, P

Kazatchkine, MD

Bélec, L

机构：

[1] Univ Paris 06, INSERM, U430, Paris, France

[2] Hop Europeen Georges Pompidou, Paris, France

来源：

JOURNAL OF VIROLOGY | 2001年 / 75卷 / 11期

关键词：

D O I：

10.1128/JVI.75.11.5370-5374.2001

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We report that both primary and laboratory-adapted infectious human immunodeficiency virus type I (HIV-1) isolates in a cell-free form are capable of transcytosis through a tight and polarized monolayer of human endometrial cells, Trancytosis of cell-free HIV occurs in a strain-selective fashion and appears to be dependent on interactions between HIV envelope glycoproteins and Lectins on the apical membrane of the epithelial cells. These findings provide new insights into the initial events occurring during heterosexual transmission of the virus.

引用

收藏

页码：5370 / 5374

页数：5

相关论文

共 33 条

[1] Constitutive expression of stromal derived factor-1 by mucosal epithelia and its role in HIV transmission and propagation [J].

Agace, WW ;

Amara, A ;

Roberts, AI ;

Pablos, JL ;

Thelen, S ;

Uguccioni, M ;

Li, XY ;

Marsal, J ;

Arenzana-Seisdedos, F ;

Delaunay, T ;

Ebert, EC ;

Moser, B ;

Parker, CM .

CURRENT BIOLOGY, 2000, 10 (06) :325-328

[2] Transcytosis of infectious human immunodeficiency virus across a tight human epithelial cell line barrier [J].

Bomsel, M .

NATURE MEDICINE, 1997, 3 (01) :42-47

[3] Primary intestinal epithelial cells can be infected with laboratory-adapted strain HIV type 1 NDK but not with clinical primary isolates [J].

Chenine, AL ;

Matouskova, E ;

Sanchez, G ;

Reischig, J ;

Pavlikova, L ;

LeContel, C ;

Chermann, JC ;

Hirsch, I .

AIDS RESEARCH AND HUMAN RETROVIRUSES, 1998, 14 (14) :1235-1238

[4] Development of an in vitro organ culture model to study transmission of HIV-1 in the female genital tract [J].

Collins, KB ;

Patterson, BK ;

Naus, GJ ;

Landers, DV ;

Gupta, P .

NATURE MEDICINE, 2000, 6 (04) :475-479

[5] BINDING OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-I (HIV-1) GP120 TO GALACTOSYLCERAMIDE (GALCER) - RELATIONSHIP TO THE V3 LOOP [J].

COOK, DG ;

FANTINI, J ;

SPITALNIK, SL ;

GONZALEZSCARANO, F .

VIROLOGY, 1994, 201 (02) :206-214

[6] Co-expression of CXCR4/fusin and galactosylceramide in the human intestinal epithelial cell line HT-29 [J].

Delezay, O ;

Koch, N ;

Yahi, N ;

Hammache, D ;

Tourres, C ;

Tamalet, C ;

Fantini, J .

AIDS, 1997, 11 (11) :1311-1318

[7] Human immunodeficiency virus type 1 populations in blood and semen [J].

Delwart, EL ;

Mullins, JI ;

Gupta, P ;

Learn, GH ;

Holodniy, M ;

Katzenstein, D ;

Walker, BD ;

Singh, MK .

JOURNAL OF VIROLOGY, 1998, 72 (01) :617-623

[8] Sulfatide inhibits HIV-1 entry into CD4-/CXCR4+ cells [J].

Fantini, J ;

Hammache, D ;

Delézay, O ;

Piéroni, G ;

Tamalet, C ;

Yahi, N .

VIROLOGY, 1998, 246 (02) :211-220

[9] INFECTION OF COLONIC EPITHELIAL-CELL LINES BY TYPE-1 HUMAN-IMMUNODEFICIENCY-VIRUS IS ASSOCIATED WITH CELL-SURFACE EXPRESSION OF GALACTOSYLCERAMIDE, A POTENTIAL ALTERNATIVE GP120 RECEPTOR [J].

FANTINI, J ;

COOK, DG ;

NATHANSON, N ;

SPITALNIK, SL ;

GONZALEZSCARANO, F .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (07) :2700-2704

[10] Role of the glycocalyx in regulating access of microparticles to apical plasma membranes of intestinal epithelial cells: Implications for microbial attachment and oral vaccine targeting [J].

Frey, A ;

Giannasca, KT ;

Weltzin, R ;

Giannasca, PJ ;

Reggio, H ;

Lencer, WI ;

Neutra, MR .

JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 184 (03) :1045-1059

← 1 2 3 4 →