A convenient modification of the Gassman oxindole synthesis

被引：19

作者：

Wright, SW

McClure, LD

Hageman, DL

机构：

[1] Pfizer Central Research, Groton, CT 06340, Eastern Point Road

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 27期

关键词：

oxindole; sulfoxide; aniline; oxalyl chloride; cyclization;

D O I：

10.1016/0040-4039(96)00920-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A modification of the Gassman oxindole synthesis is described that proceeds from anilines and ethyl (methylsulfinyl)acelate, using oxalyl chloride to activate the sulfoxide to facilitate the formation of the key N - S bonded intermediate. This procedure is particularly convenient for reactions carried out on smaller scales and for anilines that are susceptible to electrophilic halogenation. Copyright (C) 1996 Elsevier Science Ltd

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页码：4631 / 4634

页数：4

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