3-[[4-(4-chlorophenyl)piperazin-1-yl]methyl]-1H-pyrrolo[2,3-b]pyridine: An antagonist with high affinity and selectivity for the human dopamine D-4 receptor

被引：252

作者：

Kulagowski, JJ

Broughton, HB

Curtis, NR

Mawer, IM

Ridgill, MP

Baker, R

Emms, F

Freedman, SB

Marwood, R

Patel, S

Ragan, CI

Leeson, PD

机构：

[1] Merck Sharp and Dohme Res. Labs., Neuroscience Research Centre, Harlow, Essex CM20 2QR, Terlings Park, Eastwick Road

来源：

关键词：

D O I：

10.1021/jm9600712

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

[No abstract available]

引用

页码：1941 / 1942

页数：2

共 22 条

[1] DOPAMINE RECEPTOR-BINDING PREDICTS CLINICAL AND PHARMACOLOGICAL POTENCIES OF ANTI-SCHIZOPHRENIC DRUGS
CREESE, I
BURT, DR
SNYDER, SH
[J]. SCIENCE, 1976, 192 (4238) : 481 - 483
[2] DAVIS KL, 1991, AM J PSYCHIAT, V148, P1474
[3] CLOZAPINE - A REVIEW OF ITS PHARMACOLOGICAL PROPERTIES, AND THERAPEUTIC USE IN SCHIZOPHRENIA
FITTON, A
HEEL, RC
[J]. DRUGS, 1990, 40 (05) : 727 - 747
[4] FREEDMAN SB, 1994, J PHARMACOL EXP THER, V268, P417
[5] Grandy D K, 1992, Curr Opin Neurobiol, V2, P275, DOI 10.1016/0959-4388(92)90115-2
[6] Howard Harry R., 1994, Drugs of the Future, V19, P560
[7] CLOZAPINE-ASSOCIATED AGRANULOCYTOSIS - RISK AND ETIOLOGY
KRUPP, P
BARNES, P
[J]. BRITISH JOURNAL OF PSYCHIATRY, 1992, 160 : 38 - 40
[8] LOWE JA, 1994, CURR MED CHEM, V1, P50
[9] FUNCTIONAL COUPLING OF HUMAN D-2, D-3, AND D-4 DOPAMINE-RECEPTORS IN HEK293 CELLS
MCALLISTER, G
KNOWLES, MR
WARDBOOTH, SM
SINCLAIR, HA
PATEL, S
MARWOOD, R
EMMS, F
PATEL, S
SMITH, A
SEABROOK, GR
FREEDMAN, SB
[J]. JOURNAL OF RECEPTOR AND SIGNAL TRANSDUCTION RESEARCH, 1995, 15 (1-4): : 267 - 281
[10] MELTZER HY, 1989, J PHARMACOL EXP THER, V251, P238