How Does Type 1 Diabetes Develop? The Notion of Homicide or β-Cell Suicide Revisited

被引：180

作者：

Atkinson, Mark A. ^{[1
,2
]}

Bluestone, Jeffrey A. ^{[3
,4
]}

Eisenbarth, George S. ^{[5
]}

Hebrok, Matthias ^{[3
,4
]}

Herold, Kevan C. ^{[6
,7
]}

Accili, Domenico ^{[8
]}

Pietropaolo, Massimo ^{[9
]}

Arvan, Peter R. ^{[9
]}

Von Herrath, Matthias ^{[10
]}

Markel, Dorene S. ^{[11
]}

Rhodes, Christopher J. ^{[12
]}

机构：

[1] Univ Florida, Dept Pediat, Gainesville, FL 32610 USA

[2] Univ Florida, Dept Pathol, Gainesville, FL 32611 USA

[3] Univ Calif San Francisco, Ctr Diabet, San Francisco, CA 94143 USA

[4] Univ Calif San Francisco, Dept Med, San Francisco, CA USA

[5] Univ Colorado, Barbara Davis Ctr Childhood Diabet, Aurora, CO USA

[6] Yale Univ, Dept Immunobiol, New Haven, CT USA

[7] Yale Univ, Dept Internal Med, New Haven, CT USA

[8] Columbia Univ, Dept Med, New York, NY USA

[9] Univ Michigan, Dept Internal Med, Ann Arbor, MI 48109 USA

[10] La Jolla Inst Allergy & Immunol, Ctr Type Diabet Res 1, La Jolla, CA USA

[11] Univ Michigan, Dept Med Educ, Ann Arbor, MI 48109 USA

[12] Univ Chicago, Dept Med, Chicago, IL 60637 USA

来源：

DIABETES | 2011年 / 60卷 / 05期

关键词：

INSULIN-SECRETION; NOD MICE; T-CELLS; PANCREATIC-ISLETS; MELLITUS; EXPRESSION; PROINSULIN; GLUCOSE; TRANSPLANTATION; NORMOGLYCEMIA;

D O I：

10.2337/db10-1797

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

[No abstract available]

引用

页码：1370 / 1379

页数：10

共 57 条

[1] The honeymoon phase: intersection of metabolism and immunology [J].

Aly, Hanan ;

Gottlieb, Peter .

CURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY, 2009, 16 (04) :286-292

[2] Type 1 diabetes: new perspectives on disease pathogenesis and treatment [J].

Atkinson, MA ;

Eisenbarth, GS .

LANCET, 2001, 358 (9277) :221-229

[3] Genetics, pathogenesis and clinical interventions in type 1 diabetes [J].

Bluestone, Jeffrey A. ;

Herold, Kevan ;

Eisenbarth, George .

NATURE, 2010, 464 (7293) :1293-1300

[4] DEATH OF A BETA-CELL - HOMICIDE OR SUICIDE [J].

BOTTAZZO, GF .

DIABETIC MEDICINE, 1986, 3 (02) :119-130

[5] Recovery of Endogenous β-Cell Function in Nonhuman Primates After Chemical Diabetes Induction and Islet Transplantation [J].

Bottino, Rita ;

Criscimanna, Angela ;

Casu, Anna ;

He, Jing ;

Van der Windt, Dirk J. ;

Rudert, William A. ;

Giordano, Carla ;

Trucco, Massimo .

DIABETES, 2009, 58 (02) :442-447

[6] Metabolic diapause in pancreatic β-cells expressing a gain-of-function mutant of the forkhead protein Foxo1 [J].

Buteau, Jean ;

Shlien, Adam ;

Foisy, Sylvain ;

Accili, Domenico .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (01) :287-293

[7] Polycomb protein Ezh2 regulates pancreatic β-cell Ink4a/Arf expression and regeneration in diabetes mellitus [J].

Chen, Hainan ;

Gu, Xueying ;

Su, I-hsin ;

Bottino, Rita ;

Contreras, Juan L. ;

Tarakhovsky, Alexander ;

Kim, Seung K. .

GENES & DEVELOPMENT, 2009, 23 (08) :975-985

[8] C-Peptide Levels and Insulin Independence Following Autologous Nonmyeloablative Hematopoietic Stem Cell Transplantation in Newly Diagnosed Type 1 Diabetes Mellitus [J].

Couri, Carlos E. B. ;

Oliveira, Maria C. B. ;

Stracieri, Ana B. P. L. ;

Moraes, Daniela A. ;

Pieroni, Fabiano ;

Barros, George M. N. ;

Madeira, Maria Isabel A. ;

Malmegrim, Kelen C. R. ;

Foss-Freitas, Maria C. ;

Simoes, Belinda P. ;

Martinez, Edson Z. ;

Foss, Milton C. ;

Burt, Richard K. ;

Voltarelli, Julio C. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2009, 301 (15) :1573-1579

[9] Metabolic control of β-cell function [J].

Deeney, JT ;

Prentki, M ;

Corkey, BE .

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2000, 11 (04) :267-275

[10] Bmi-1 regulates the Ink4a/Arf locus to control pancreatic β-cell proliferation [J].

Dhawan, Sangeeta ;

Tschen, Shuen-Ing ;

Bhushan, Anil .

GENES & DEVELOPMENT, 2009, 23 (08) :906-911

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