[1] Univ Calif San Diego, Dept Med, Div Cardiol, La Jolla, CA 92093 USA
[2] Shinshu Univ, Sch Med, Dept Internal Med 1, Matsumoto, Nagano 390, Japan
[3] Konan St Hill Hosp, Dept Cardiol, Ube, Yamaguchi 7590204, Japan
[4] Genentech Inc, San Francisco, CA 94080 USA
[5] Univ Auckland, Sch Med, Res Ctr Dev Med & Biol, Auckland, New Zealand