Palladium-catalyzed intramolecular hydroalkylation of unactivated olefins with dialkyl ketones

被引：73

作者：

Wang, X ^{[1
]}

Pei, T ^{[1
]}

Han, XQ ^{[1
]}

Widenhoefer, RA ^{[1
]}

机构：

[1] Duke Univ, PM Gross Chem Lab, Durham, NC 27708 USA

来源：

ORGANIC LETTERS | 2003年 / 5卷 / 15期

关键词：

D O I：

10.1021/ol034879+

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Treatment of 3-butenyl heptyl ketone with substoichiometric amounts of PdCl2(CH3CN)(2) (10 mol %), HCl (0.1 equiv), and CuCl2 (0.3 equiv) in dioxane at 70 degreesC for 12 h in a sealed tube formed 2-hexylcyclohexanone in 77% isolated yield. A number of alkyl 3-butenyl ketones underwent hydroalkylation under these conditions to form 2-substituted cyclohexanones in moderate to good yield.

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页码：2699 / 2701

页数：3

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