Optical heterodyne surface-plasmon resonance biosensor

被引：56

作者：

Kuo, WC ^{[1
]}

Chou, C

Wu, HT

机构：

[1] Natl Yang Ming Univ, Inst Radiol Sci, Taipei 112, Taiwan

[2] Natl Yang Ming Univ, Dept Med Radiat Technol, Taipei 112, Taiwan

来源：

OPTICS LETTERS | 2003年 / 28卷 / 15期

关键词：

D O I：

10.1364/OL.28.001329

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

A novel optical heterodyne surface-plasmon resonance (SPR) biosensor with a Zeeman laser is proposed. Two surface plasma waves are excited by two correlated p-polarized waves in a SPR device of the Kretschmann configuration. Two reflected p waves are optically heterodyned such that the magnitude of the heterodyned signal is proportional to the multiplication of two attenuated reflected p waves. Then the detection sensitivity and the dynamic range based on this amplitude-sensitive method are enhanced. In the experiment, the kinetics between mouse immunoglobulin G (IgG) and rabbit antimouse IgG is obtained from sensograms of various concentrations of antimouse IgG. A detection sensitivity of 0.2 nM was achieved. In addition, a concentration of 5 ng/ml of protein G interacting with mouse IgG was measured successfully. (C) 2003 Optical Society of America.

引用

页码：1329 / 1331

页数：3

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