Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Pharmacogenetics-Guided Warfarin Dosing: 2017 Update

被引：541

作者：

Johnson, J. A. ^{[1
,2
]}

Caudle, K. E. ^{[3
]}

Gong, L. ^{[4
]}

Whirl-Carrillo, M. ^{[4
]}

Stein, C. M. ^{[5
]}

Scott, S. A. ^{[6
]}

Lee, M. T. ^{[7
,8
,9
,10
]}

Gage, B. F. ^{[11
]}

Kimmel, S. E. ^{[12
,13
,14
]}

Perera, M. A. ^{[15
]}

Anderson, J. L. ^{[16
,17
]}

Pirmohamed, M. ^{[18
,19
,20
]}

Klein, T. E. ^{[4
]}

Limdi, N. A. ^{[21
]}

Cavallari, L. H. ^{[1
,2
]}

Wadelius, M. ^{[22
]}

机构：

[1] Univ Florida, Coll Pharm, Dept Pharmacotherapy & Translat Res, Gainesville, FL 32611 USA

[2] Univ Florida, Ctr Pharmacogen, Gainesville, FL 32611 USA

[3] St Jude Childrens Res Hosp, Dept Pharmaceut Sci, 332 N Lauderdale St, Memphis, TN 38105 USA

[4] Stanford Univ, Dept Biomed Data Sci, Stanford, CA 94305 USA

[5] Vanderbilt Univ Sch Med, Div Clin Pharmacol, Nashville, TN USA

[6] Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, New York, NY 10029 USA

[7] RIKEN Ctr Integrat Med Sci, Lab Int Alliance Genom Res, Yokohama, Kanagawa, Japan

[8] Acad Sinica, Natl Ctr Genome Med, Taipei, Taiwan

[9] Acad Sinica, Inst Biomed Sci, Taipei, Taiwan

[10] Geisinger Hlth Syst, Genom Med Inst, Danville, PA USA

[11] Washington Univ, Dept Internal Med, St Louis, MO USA

[12] Univ Penn, Sch Med, Ctr Clin Epidemiol & Biostat, Philadelphia, PA 19104 USA

[13] Univ Penn, Sch Med, Dept Med, Philadelphia, PA 19104 USA

[14] Univ Penn, Sch Med, Dept Biostat & Epidemiol, Philadelphia, PA 19104 USA

[15] Univ Chicago, Dept Med, 5841 S Maryland Ave, Chicago, IL 60637 USA

[16] Univ Utah, Sch Med, Intermt Med Ctr, Intermt Heart Inst, Salt Lake City, UT USA

[17] Univ Utah, Sch Med, Dept Internal Med Cardiol, Salt Lake City, UT USA

[18] Univ Liverpool, Dept Mol & Clin Pharmacol, Liverpool, Merseyside, England

[19] Univ Liverpool, Wolfson Ctr Personalised Med, Liverpool, Merseyside, England

[20] Univ Liverpool, Inst Translat Med, Liverpool, Merseyside, England

[21] Univ Alabama Birmingham, Dept Neurol & Epidemiol, Birmingham, AL USA

[22] Uppsala Univ, Dept Med Sci, Clin Pharmacol & Sci Life Lab, Uppsala, Sweden

来源：

CLINICAL PHARMACOLOGY & THERAPEUTICS | 2017年 / 102卷 / 03期

基金：

瑞典研究理事会; 美国国家卫生研究院; 英国医学研究理事会;

关键词：

DOSE REQUIREMENT; AFRICAN-AMERICANS; VKORC1; CYP4F2; POLYMORPHISMS; THERAPY; CYP2C9; VARIABILITY; ALGORITHMS; GENOTYPE;

D O I：

10.1002/cpt.668

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

This document is an update to the 2011 Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline for CYP2C9 and VKORC1 genotypes and warfarin dosing. Evidence from the published literature is presented for CYP2C9, VKORC1, CYP4F2, and rs12777823 genotype-guided warfarin dosing to achieve a target international normalized ratio of 2-3 when clinical genotype results are available. In addition, this updated guideline incorporates recommendations for adult and pediatric patients that are specific to continental ancestry.

引用

页码：397 / 404

页数：8

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