Phosphatases in cell-matrix adhesion and migration

被引：104

作者：

Larsen, M ^{[1
]}

Tremblay, ML

Yamada, KM

机构：

[1] McGill Univ, Ctr Canc, Montreal, PQ H3G 1Y6, Canada

[2] McGill Univ, Dept Biochem, Montreal, PQ H3G 1Y6, Canada

[3] Natl Inst Dent & Craniofacial Res, Craniofacial Dev Biol & Regenerat Branch, NIH, Bethesda, MD 20892 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2003年 / 4卷 / 09期

关键词：

D O I：

10.1038/nrm1199

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Many proteins that have been implicated in cell-matrix adhesion and cell migration are phosphorylated, which regulates their folding, enzymatic activities and protein-protein interactions. Although modulation of cell motility by kinases is well known, increasing evidence confirms that phosphatases are essential at each stage of the migration process. Phosphatases can control the formation and maintenance of the actin cytoskeleton, regulate small GTPase molecular switches, and modulate the dynamics of matrix-adhesion interaction, actin contraction, rear release and migratory directionality.

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页码：700 / 711

页数：12

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