Optimal check size and reversal rate to elicit pattern-reversal MEG responses

Objective: To determine the impact of check size and interstimulus interval (ISI) on neuromagnetic visual cortical responses. Methods: We recorded visual evoked fields to pattern-reversal stimulation with central occlusion in ten subjects. The similar to 100 ms magnetic activation (P100m) was analyzed by single dipole modeling. Results: With Is ISI, P100m strengths increased as check size increased from 15' up to 120' of visual arc, and larger checks elicited less P100m activation. With 120' checks, we found no P 100m attenuation as ISI decreased from 4 s to 0. 16 s. P 100m sources around the calcarine sulcus did not vary with check size or ISI. Conclusions: The magnitude of cortical activation during visual contrast processing is check size-dependent and the 120' checks are optimum for future studies on neuromagnetic visual cortical functions using central-occluded stimulation. The corresponding neuronal activation demonstrated a short refractory period less than 0. 16 s. We also found significantly overlapping cortical representation areas for different check sizes or ISIS.