Quantitative cell biology with the virtual cell

被引：178

作者：

Slepchenko, BM

Schaff, JC

Macara, I

Loew, LM ^{[1
]}

机构：

[1] Univ Connecticut, Ctr Hlth, Ctr Biomed Imaging Technol & Natl Resource Cell A, Dept Physiol, Farmington, CT 06030 USA

[2] Univ Virginia, Ctr Cell Signaling, Charlottesville, VA 22908 USA

[3] Univ Virginia, Dept Pharmacol, Charlottesville, VA 22908 USA

来源：

TRENDS IN CELL BIOLOGY | 2003年 / 13卷 / 11期

关键词：

D O I：

10.1016/j.tcb.2003.09.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cell biological processes are controlled by an interacting set of biochemical and electrophysiological events that are distributed within complex cellular structures. Computational models, comprising quantitative data on the interacting molecular participants in these events, provide a means for applying the scientific method to these complex systems. The Virtual Cell is a computational environment designed for cell biologists, to facilitate the construction of models and the generation of predictive simulations from them. This review summarizes how a Virtual Cell model is assembled and describes the physical principles underlying the calculations that are performed. Applications to problems in nucleocytoplasmic transport and intracellular calcium dynamics will illustrate the power of this paradigm for elucidating cell biology.

引用

页码：570 / 576

页数：7

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