STAT3: A Target to Enhance Antitumor Immune Response

被引：113

作者：

Lee, Heehyoung ^{[4
]}

Pal, Sumanta Kumar ^{[3
]}

Reckamp, Karen ^{[2
]}

Figlin, Robert A.

Yu, Hua ^{[1
]}

机构：

[1] City Hope Comprehens Canc Ctr, Canc Immunotherapeut & Tumor Immunol, Duarte, CA 91010 USA

[2] City Hope Comprehens Canc Ctr, Dept Med Oncol & Expt Therapeut, Div Thorac Malignancies, Duarte, CA 91010 USA

[3] City Hope Comprehens Canc Ctr, Dept Med Oncol & Expt Therapeut, Div Genitourinary Malignancies, Duarte, CA 91010 USA

[4] City Hope Comprehens Canc Ctr, Beckman Res Inst, Duarte, CA 91010 USA

来源：

CANCER IMMUNOLOGY AND IMMUNOTHERAPY | 2011年 / 344卷

关键词：

REGULATORY T-CELLS; CHRONIC MYELOID-LEUKEMIA; SUPPRESSOR-CELLS; DENDRITIC CELLS; SIGNAL TRANSDUCER; TUMOR MICROENVIRONMENT; TYROSINE KINASE; IMATINIB MESYLATE; INHIBITING STAT3; INTERFERON-ALPHA;

D O I：

10.1007/82_2010_51

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Signal transducer and activator of transcription 3 (Stat3) has emerged as a critical regulator for tumor-associated inflammation. Activation of Stat3 negatively regulates the Th1-type immune response and promotes expansion of myeloid-derived suppressor cells (MDSCs) and regulatory T-cell functions in the tumor microenvironment. Mounting evidence suggests that Stat3 and related pathways may serve as a target for changing the tumor immunologic microenvironment to benefit cancer immunotherapies. Many recent studies support the use of certain tyrosine kinase inhibitors, through inhibition of Stat3, in decreasing immunosuppression in the tumor microenvironment. Other potential therapeutic avenues include the use of targeted delivery of Stat3 siRNA into immune cells. Here, we describe the role of Stat3 in regulating the immunologic properties of tumors as a background for Stat3-based therapeutic interventions.

引用

页码：41 / 59

页数：19

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