Established and new treatments for hereditary angioedema: An update

被引：15

作者：

Cicardi, Marco ^{[1
]}

Zingale, Lorenza ^{[1
]}

Zanichelli, Andrea ^{[1
]}

Deliliers, Daniela Lambertenghi ^{[1
]}

机构：

[1] Univ Milan, Dept Internal Med, Osped L Sacco, I-20122 Milan, Italy

来源：

MOLECULAR IMMUNOLOGY | 2007年 / 44卷 / 16期

关键词：

hereditary angioedema; HAE; C1-inhibitor; therapy;

D O I：

10.1016/j.molimm.2007.06.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Hereditary angioedema (HAE) is due to inherited deficiency of C1-inhibitor (C1-INH) and causes localized swelling that may be life-threatening when it affects the larynx. Replacement therapy with plasma derived C1-INH has been the principal life saving treatment for more than 20 years in several European countries. Nevertheless, it is not licensed in U.S. and even in Europe it is mostly supplied on a named patient basis. In the last 5 years, controlled clinical trials with four products (plasma derived C1-INH, the enzyme inhibitor Dx-88, the receptor antagonist Icatibant and a recombinant form of human C1-INH) have been performed or initiated in order to demonstrate their efficacy in reverting symptoms of HAE. Here we review the characteristics of these products and the current situation of the trials. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：3858 / 3861

页数：4

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