Gradual changes in hippocampal activity support remembering the order of events

被引：287

作者：

Manns, Joseph R.

Howard, Marc W.

Eichenbaum, Howard ^{[1
]}

机构：

[1] Boston Univ, Ctr Memory & Brain, Boston, MA 02215 USA

[2] Syracuse Univ, Dept Psychol, Syracuse, NY 13244 USA

来源：

NEURON | 2007年 / 56卷 / 03期

关键词：

D O I：

10.1016/j.neuron.2007.08.017

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The hippocampus is thought to contribute to episodic memory in part by binding stimuli to their spatiotemporal context. The present study examined how hippocampal neuronal populations encode spatial and temporal context as rats performed a task in which they were required to remember the order of trial-unique sequences of odors. The results suggest that a gradual change in the pattern of hippocampal activity served as a temporal context for odor-sampling events and was important for successful subsequent memory of the order of those odors.

引用

收藏

页码：530 / 540

页数：11

相关论文

共 29 条

[1] Memory for events and their spatial context: models and experiments [J].

Burgess, N ;

Becker, S ;

King, JA ;

O'Keefe, J .

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2001, 356 (1413) :1493-1503

[2] Computational models of working memory: putting long-term memory into context [J].

Burgess, N ;

Hitch, G .

TRENDS IN COGNITIVE SCIENCES, 2005, 9 (11) :535-541

[3] Theta rhythm of navigation:: Link between path integration and landmark navigation, episodic and semantic memory [J].

Buzsáki, G .

HIPPOCAMPUS, 2005, 15 (07) :827-840

[4] Neuronal oscillations in cortical networks [J].

Buzsáki, G ;

Draguhn, A .

SCIENCE, 2004, 304 (5679) :1926-1929

[5] Temporal encoding of place sequences by hippocampal cell assemblies [J].

Dragoi, G ;

Buzsáki, G .

NEURON, 2006, 50 (01) :145-157

[6] Hippocampus: Cognitive processes and neural representations that underlie declarative memory [J].

Eichenbaum, H .

NEURON, 2004, 44 (01) :109-120

[7] The medial temporal lobe and recognition memory [J].

Eichenbaum, H. ;

Yonelinas, A. P. ;

Ranganath, C. .

ANNUAL REVIEW OF NEUROSCIENCE, 2007, 30 :123-152

[8] STATISTICAL THEORY OF SPONTANEOUS RECOVERY AND REGRESSION [J].

ESTES, WK .

PSYCHOLOGICAL REVIEW, 1955, 62 (03) :145-154

[9] Critical role of the hippocampus in memory for sequences of events [J].

Fortin, NJ ;

Agster, KL ;

Eichenbaum, HB .

NATURE NEUROSCIENCE, 2002, 5 (05) :458-462

[10] Delay-period activity in the primate prefrontal cortex encoding multiple spatial positions and their order of presentation [J].

Funahashi, S ;

Inoue, M ;

Kubota, K .

BEHAVIOURAL BRAIN RESEARCH, 1997, 84 (1-2) :203-223