The development of clinical signs of rheumatoid synovial inflammation is associated with increased synthesis of the chemokine CXCL8 (interleukin-8)

被引：94

作者：

Kraan, MC

Patel, DD

Haringman, JJ

Smith, MD

Weedon, H

Ahern, MJ

Breedveld, FC

Tak, PP

机构：

[1] Univ Amsterdam, Acad Med Ctr, Dept Med, Div Clin Immunol & Rheumatol, NL-1105 AZ Amsterdam, Netherlands

[2] Duke Univ, Med Ctr, Dept Med, Div Rheumatol Allergy & Clin Immunol, Durham, NC 27710 USA

[3] Repatriat Gen Hosp, Daw Pk, SA, Australia

[4] Leiden Univ, Med Ctr, Dept Rheumatol, Leiden, Netherlands

来源：

ARTHRITIS RESEARCH | 2001年 / 3卷 / 01期

关键词：

arthritis; chemokines; CXCL8; patients; synovium;

D O I：

10.1186/ar141

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Paired synovial tissue samples were obtained from both clinically uninvolved (CU) and clinically involved (CI) knee joints of eight rheumatoid arthritis (RA) patients. In addition, biopsies were taken from five control subjects. We observed the expression of the chemokines CXCL8, CXCL9, CXCL10, CCL2 and CCL4 in CI and CU joints of RA patients. In particular, CXCL8 protein levels were specifically increased in CI joints compared with CU joints, which was confirmed by immunohistochemistry and in situ hybridization.

引用

页码：65 / 71

页数：7

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