Expedient synthesis of hydroxytyrosol and its esters

被引:31
作者
Bovicelli, Paolo [1 ]
Antonioletti, Roberto [1 ]
Mancini, Silvia [1 ]
Causio, Stefano [1 ]
Borioni, Giorgio [2 ]
Annnendola, Sergio [3 ]
Barontini, Maurizio [4 ]
机构
[1] Univ Roma La Sapienza, CNR, Inst Biomol Chem, Dept Chem, I-00185 Rome, Italy
[2] SynthActive, Rome, Italy
[3] Ambiotec, Rome, Italy
[4] Univ Tuscia, Viterbo, Italy
关键词
antioxidants; hydroxytyrosol; polyphenols;
D O I
10.1080/00397910701575509
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
An efficient and friendly method for obtaining hydroxytyrosol from tyrosol, a component of olive waste, is reported. Hydroxytyrosol also may be obtained in the form of enzymatically convertible precursors (e.g., hydroxytyrosyl acetate), thus increasing the stability of the active principle.
引用
收藏
页码:4245 / 4252
页数:8
相关论文
共 12 条
[1]  
Alcudia F., 2004, [No title captured], Patent No. [2004005237, PCT 2004005237]
[2]   METAL IONS AND COMPLEXES IN ORGANIC REACTIONS .7. COPPER-PROMOTED HYDROGEN TRANSFER FROM AROMATIC DONORS TO HALIDES [J].
BACON, RGR ;
STEWART, OJ .
JOURNAL OF THE CHEMICAL SOCIETY C-ORGANIC, 1969, (02) :301-&
[3]  
BOVICELLI P, 2001, SYNTHETIC COMMUN
[4]   Phenolic compounds in Spanish olive oils [J].
Brenes, M ;
García, A ;
García, P ;
Rios, JJ ;
Garrido, A .
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 1999, 47 (09) :3535-3540
[5]   Antioxidant properties of low molecular weight phenols present in the Mediterranean diet [J].
Briante, R ;
Febbraio, F ;
Nucci, R .
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2003, 51 (24) :6975-6981
[6]  
Fernandez- Bolanos G.J., 2004, [No title captured], Patent No. [2004102657, U.S. 2004102657]
[7]   The role of hydrogen bonding on the H-atom-donating abilities of catechols and naphthalene diols and on a previously overlooked aspect of their infrared spectra [J].
Foti, MC ;
Barclay, LRC ;
Ingold, KU .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2002, 124 (43) :12881-12888
[8]   Protective effects of synthetic hydroxytyrosol acetyl derivatives against oxidative stress in human cells [J].
Manna, C ;
Migliardi, V ;
Sannino, F ;
De Martino, A ;
Capasso, R .
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2005, 53 (24) :9602-9607
[9]   The phenolic compounds of olive oil: structure, biological activity and beneficial effects on human health [J].
Tripoli, E ;
Giammanco, M ;
Tabacchi, G ;
Di Majo, D ;
Giammanco, S ;
La Guardia, M .
NUTRITION RESEARCH REVIEWS, 2005, 18 (01) :98-112
[10]   Synthesis of tritium-labeled hydroxytyrosol, a phenolic compound found in olive oil [J].
Tuck, KL ;
Tan, HW ;
Hayball, PJ .
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2000, 48 (09) :4087-4090