Organization of cell-regulatory systems through modular-protein-interaction domains

被引:16
作者
Pawson, T
机构
[1] Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada
[2] Univ Toronto, Dept Mol & Med Genet, Toronto, ON M5S 1A8, Canada
来源
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES | 2003年 / 361卷 / 1807期
关键词
signal transduction; protein complexes; phosphorylation; SH2; domains;
D O I
10.1098/rsta.2003.1197
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Cells are organized through the interactions of proteins with one another, and with phospholipids, nucleic acids and small molecules, suggesting a molecular recognition code for cell assembly. These interactions are mediated by a, set of conserved protein interaction domains, which regulate the dynamic behaviour of the cell, and are used to build protein complexes and networks with emergent properties. Cell regulatory proteins have a modular architecture, which may have facilitated the evolution of new signalling pathways, and is exploited by pathogenic micro-organisms and chimeric oncoproteins to re-specify cellular function.
引用
收藏
页码:1251 / 1262
页数:12
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