An efficient synthesis of C2-symmetric chiral binaphthyl ketone catalysts

被引：7

作者：

Furutani, T ^{[1
]}

Hatsuda, M ^{[1
]}

Shimizu, T ^{[1
]}

Seki, M ^{[1
]}

机构：

[1] Tanabe Seiyaku Co Ltd, Prod & Technol Dev Lab, Yodogawa Ku, Osaka 5328505, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2001年 / 65卷 / 01期

关键词：

biaryls; enzymic reaction; kinetic resolution; acylation;

D O I：

10.1271/bbb.65.180

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An efficient synthesis of C-2-symmetric chiral binaphthyl ketones 1a and b, effective catalysts for asymmetric epoxidation, is reported, The key features of this synthesis are Co(salen)-catalyzed macrolactonization of racemic 1,1'-binaphthyl-2,2'-dicarboxylic acid monoglycidyl esters 3a and b and lipase-catalyzed enantioselective acylation of resulting 11-membered cyclic binaphthyl alcohols 4a and b.

引用

页码：180 / 184

页数：5

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