A simple, user-friendly process for the homologation of aldehydes using tosylhydrazone salts

被引：31

作者：

Aggarwal, VK

de Vicente, J

Pelotier, B

Holmes, IP

Bonnert, RV

机构：

[1] Univ Sheffield, Dept Chem, Sheffield S3 7HF, S Yorkshire, England

[2] AstraZeneca R&D Charnwood, Med Chem, Loughborough LE11 5RH, Leics, England

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 52期

基金：

英国工程与自然科学研究理事会;

关键词：

D O I：

10.1016/S0040-4039(00)01856-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Aldehydes can be homologated to ketones in moderate to good yields using aryldiazomethanes generated in situ from tosylhydrazones. Chiral aldehydes can be employed with almost complete retention of configuration. The tosylhydrazones can also be generated in situ from the corresponding aldehyde leading to a one-pot process for coupling two different carbonyl compounds to give ketones. (C) 2000 Elsevier Science Ltd. All rights reserved.

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页码：10327 / 10331

页数：5

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