Multiresolution imaging of MEG cortical sources using an explicit piecewise model

被引:26
作者
Cottereau, Benoit
Jerbi, Karim
Baillet, Sylvain
机构
[1] Univ Paris 06, Cognit Neurosci & Brain Imaging Lab, Hop La Salpetriere, CNRS,UPR 640,LENA, F-75651 Paris 13, France
[2] ESME Sudria Coll Engn, Ivry, France
关键词
electromagnetic brain imaging; MEG; current multipole expansion; multiresolution; generalized cross-validation; model selection; optimization;
D O I
10.1016/j.neuroimage.2007.07.046
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Imaging neural generators from MEG magnetic fields is often considered as a compromise between computationally-reasonable methodology that usually yields poor spatial resolution on the one hand, and more sophisticated approaches on the other hand, potentially leading to intractable computational costs. We approach the problem of obtaining well-resolved source images with unexcessive computation load with a multiresolution image model selection (MiMS) technique. The building blocks of the MiMS source model are parcels of the cortical surface which can be designed at multiple spatial resolutions with the combination of anatomical and functional priors. Computation charge is reduced owing to 1) compact parametric models of the activation of extended brain parcels using current multipole expansions and 2) the optimization of the generalized cross-validation error on image models, which is closed-form for the broad class of linear estimators of neural currents. Model selection can be complemented by any conventional imaging approach of neural currents restricted to the optimal image support obtained from MiMS. The estimation of the location and spatial extent of brain activations is discussed and evaluated using extensive Monte-Carlo simulations. An experimental evaluation was conducted with MEG data, from a somatotopic paradigm. Results show that MiMS is an efficient image model selection technique with robust performances at realistic noise levels. (c) 2007 Elsevier Inc. All rights reserved.
引用
收藏
页码:439 / 451
页数:13
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