Inbreeding abolishes the effect of parental origin of a mutant Rb-1 allele on pituitary tumorigenesis in mice

被引：2

作者：

Armstrong, JF

Hooper, ML

机构：

[1] Univ Edinburgh, Western Gen Hosp, Sir Alastair Currie CRC Labs, Mol Med Ctr, Edinburgh EH4 2XU, Midlothian, Scotland

[2] Univ Edinburgh, Dept Pathol, Edinburgh EH8 9AG, Midlothian, Scotland

来源：

BRITISH JOURNAL OF CANCER | 1998年 / 78卷 / 04期

基金：

英国医学研究理事会;

关键词：

Rb-1; retinoblastoma; pituitary tumour; imprinting;

D O I：

10.1038/bjc.1998.519

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The previously reported earlier onset of pituitary tumours in cross-bred mice inheriting a mutant Rb-1 allele paternally has been ascribed to imprinting of an Rb-1-linked gene. Here, we demonstrate that, as predicted from this mechanism, there is no effect of the parent of origin of the mutation in inbred mice.

引用

页码：484 / 485

页数：2

共 11 条

[1] GAMETIC IMPRINTING IN MAMMALS [J].

BARLOW, DP .

SCIENCE, 1995, 270 (5242) :1610-1613

[2] REQUIREMENT FOR A FUNCTIONAL RB-1 GENE IN MURINE DEVELOPMENT [J].

CLARKE, AR ;

MAANDAG, ER ;

VANROON, M ;

VANDERLUGT, NMT ;

VANDERVALK, M ;

HOOPER, ML ;

BERNS, A ;

RIELE, HT .

NATURE, 1992, 359 (6393) :328-330

[3]

HARRISON DJ, 1995, ONCOGENE, V10, P1615

[4]

HU NP, 1994, ONCOGENE, V9, P1021

[5] EFFECTS OF AN RB MUTATION IN THE MOUSE [J].

JACKS, T ;

FAZELI, A ;

SCHMITT, EM ;

BRONSON, RT ;

GOODELL, MA ;

WEINBERG, RA .

NATURE, 1992, 359 (6393) :295-300

[6] MUTATION AND CANCER - STATISTICAL STUDY OF RETINOBLASTOMA [J].

KNUDSON, AG .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1971, 68 (04) :820-&

[7] ANTIONCOGENES AND HUMAN CANCER [J].

KNUDSON, AG .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (23) :10914-10921

[8]

Lee E. T., 1992, Statistical Methods for Survival Data Analysis, V2nd

[9]

Nikitin AY, 1997, CANCER RES, V57, P4274

[10] PREFERENTIAL MUTATION OF PATERNALLY DERIVED RB GENE AS THE INITIAL EVENT IN SPORADIC OSTEO-SARCOMA [J].

TOGUCHIDA, J ;

ISHIZAKI, K ;

SASAKI, MS ;

NAKAMURA, Y ;

IKENAGA, M ;

KATO, M ;

SUGIMOT, M ;

KOTOURA, Y ;

YAMAMURO, T .

NATURE, 1989, 338 (6211) :156-158

← 1 2 →