A simple procedure for solid-phase synthesis of peptide nucleic acids with N-terminal cysteine

被引：16

作者：

Goodwin, TE

Holland, RD

Lay, JO

Raney, KD

机构：

[1] Univ Arkansas Med Sci, Dept Biochem & Mol Biol, Little Rock, AR 72205 USA

[2] Hendrix Coll, Dept Chem, Conway, AR 72032 USA

[3] US FDA, Natl Ctr Toxicol Res, Jefferson, AR 72079 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 16期

关键词：

D O I：

10.1016/S0960-894X(98)00400-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Problems were encountered during attempts to prepare N-terminal cysteine-substituted peptide nucleic acids (PNAs) from commercially available, Fmoc-protected monomers. These problems have been surmounted by the use of an S-t-butylmercapto protecting group on the cysteine moiety. The solid-phase syntheses are carried out via a simplified procedure which should be generally useful for manual PNA synthesis. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：2231 / 2234

页数：4

共 15 条

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Andreu D, 1994, Methods Mol Biol, V35, P91

[2] Peptide nucleic acid characterization by MALDI-TOF mass spectrometry [J].