The influence of vacuum mixing on methylmethacrylate liberation from acrylic cement powder

被引：15

作者：

Bettencourt, A

Calado, A

Amaral, J

Vale, FM

Rico, JMT

Monteiro, J

Castro, M

机构：

[1] Univ Lisbon, Fac Farm, P-1600083 Lisbon, Portugal

[2] Univ Lisbon, CECUL, Ctr Electroquim & Cinet, P-1699 Lisbon, Portugal

[3] Univ Lisbon, Ctr Farmacol Expt & Clin, P-1699 Lisbon, Portugal

[4] Hosp Santa Maria, Serv Ortopedia, Lisbon, Portugal

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2001年 / 219卷 / 1-2期

关键词：

poly(methylmethacrylate); methylmethacrylate; biomaterial; bone cement; release model; vacuum mixing;

D O I：

10.1016/S0378-5173(01)00630-5

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Polymethylmethacrylate (PMMA) bone cement is a biomaterial used to anchor prostheses during joint replacement surgery. Residual methylmethacrylate monomer (MNA) may be related with the cytotoxic effect of PM MA. The aim of the present paper was to investigate the effect of two different cement mixing methods: hand stirring at atmospheric pressure and under partial vacuum (0.330 and 0.154 bar) on residual monomer liberation in phosphate buffer saline solution from acrylic cement powder. Residual MMA content was determined by high-performance liquid chromatography. Mathematical models were applied to experimental dissolution data revealing that monomer release was significantly reduced in bone cement powder obtained at 0.154 bar vacuum pressure compared to the other mixing conditions. The kinetic models applied are consistent with a simple diffusion mechanism of the monomer from the polymer matrix. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：89 / 93

页数：5

共 11 条

[1] In vitro release studies of methylmethacrylate liberation from acrylic cement powder [J].

Bettencourt, A ;

Calado, A ;

Amaral, J ;

Vale, FM ;

Rico, JMT ;

Monteiro, J ;

Lopes, A ;

Pereira, L ;

Castro, M .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2000, 197 (1-2) :161-168

[2]

Brossard C., 1990, STP PHARM, V6, P728

[3]

DONBROW M, 1992, MICROCAPSULES NANOPA, P193

[4]

Lewis G, 1997, J BIOMED MATER RES, V38, P155, DOI 10.1002/(SICI)1097-4636(199722)38:2<155::AID-JBM10>3.0.CO

[5]

2-C

[6]

Smeds S, 1997, CLIN ORTHOP RELAT R, P326

[7]

*US PHARM CONV INC, 1995, NAT FORM US, V18, P2265

[8] Acrylic bone cement induces the production of free radicals by cultured human fibroblasts [J].

Vale, FM ;

Castro, M ;

Monteiro, J ;

Couto, FS ;

Pinto, R ;

Rico, JMGT .

BIOMATERIALS, 1997, 18 (16) :1133-1135

[9] CHARACTERIZATION OF BONE CEMENTS [J].

WIJN, JRD ;

SLOOFF, TJJH ;

DRIESSENS, FCM .

ACTA ORTHOPAEDICA SCANDINAVICA, 1975, 46 (01) :38-51

[10]

WILLIAMS RP, 1992, CLIN ORTHOP RELAT R, P174

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