Visual sensations produced by optic nerve stimulation using an implanted self-sizing spiral cuff electrode

被引:291
作者
Veraart, C
Raftopoulos, C
Mortimer, JT
Delbeke, J
Pins, D
Michaux, G
Vanlierde, A
Parrini, S
Wanet-Defalque, MC
机构
[1] Univ Catholique Louvain, Neural Rehabil Engn Lab, B-1200 Brussels, Belgium
[2] St Luc Univ Hosp, Dept Neurosurg, B-1200 Brussels, Belgium
[3] Case Western Reserve Univ, Dept Biomed Engn, Appl Neural Control Lab, Cleveland, OH 44106 USA
关键词
visual prosthesis; retinitis pigmentosa; optic nerve stimulation; self-sizing spiral cuff electrode;
D O I
10.1016/S0006-8993(98)00977-9
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
A blind volunteer with retinitis pigmentosa was chronically implanted with a self-sizing spiral cuff electrode around an optic nerve. Electrical stimuli applied to the nerve produced localized visual sensations that were broadly distributed throughout the visual field and could be varied by changing the stimulating conditions. These results demonstrate the potential for constructing a visual prosthesis, based on electrical stimulation of the optic nerve, for blind subjects who have intact retinal ganglion cells. (C) 1998 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:181 / 186
页数:6
相关论文
共 16 条
[1]   SOME QUANTITATIVE ASPECTS OF CATS EYE - AXIS AND PLANE OF REFERENCE, VISUAL FIELD CO-ORDINATES AND OPTICS [J].
BISHOP, PO ;
VAKKUR, GJ ;
KOZAK, W .
JOURNAL OF PHYSIOLOGY-LONDON, 1962, 163 (03) :466-&
[2]   SENSATIONS PRODUCED BY ELECTRICAL STIMULATION OF VISUAL CORTEX [J].
BRINDLEY, GS ;
LEWIN, WS .
JOURNAL OF PHYSIOLOGY-LONDON, 1968, 196 (02) :479-&
[3]  
Delbeke J, 1998, PFLUG ARCH EUR J PHY, V435, pR244
[4]   The effect of stimulus pulse duration on selectivity of neural stimulation [J].
Grill, WM ;
Mortimer, JT .
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 1996, 43 (02) :161-166
[5]  
Guilford J., 1954, Journal of Educational Psychology
[6]  
HAMBRECHT FT, 1995, NEUROPROSTHESES, P147
[7]   Visual perception elicited by electrical stimulation of retina in blind humans [J].
Humayun, MS ;
deJuan, E ;
Dagnelie, G ;
Greenberg, RJ ;
Prost, RH ;
Phillips, DH .
ARCHIVES OF OPHTHALMOLOGY, 1996, 114 (01) :40-46
[8]  
Lapicque L, 1907, J PHYSIOL-PARIS, V9, P622
[9]  
MILLER N, 1988, WALSH HOYTS CLIN NEU
[10]   A SPIRAL NERVE CUFF ELECTRODE FOR PERIPHERAL-NERVE STIMULATION [J].
NAPLES, GG ;
MORTIMER, JT ;
SCHEINER, A ;
SWEENEY, JD .
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 1988, 35 (11) :905-916