Minimal residual disease-directed preemptive treatment with azacitidine in patients with NPM1-mutant acute myeloid leukemia and molecular relapse

被引:62
作者
Sockel, Katja
Wermke, Martin
Radke, Joergen
Kiani, Alexander [2 ]
Schaich, Markus
Bornhaeuser, Martin
Ehninger, Gerhard
Thiede, Christian
Platzbecker, Uwe [1 ]
机构
[1] Univ Klinikum Carl Gustav Carus, Med Klin 1, Med Klin & Poliklin 1, D-01307 Dresden, Germany
[2] Klinikum Bayreuth, Bayreuth, Germany
来源
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL | 2011年 / 96卷 / 10期
关键词
AML; nucleophosmin; NPM1; MRD; azacitidine;
D O I
10.3324/haematol.2011.044388
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:1568 / 1570
页数:4
相关论文
共 10 条
[1]   Quantitative monitoring of NPM1 mutations provides a valid minimal residual disease parameter following allogeneic stem cell transplantation [J].
Bacher, Ulrike ;
Badbaran, Anita ;
Fehse, Boris ;
Zabelina, Tatjana ;
Zander, Axel Rolf ;
Kroeger, Nicolaus .
EXPERIMENTAL HEMATOLOGY, 2009, 37 (01) :135-142
[2]   Maintenance Therapy With Low-Dose Azacitidine After Allogeneic Hematopoietic Stem Cell Transplantation for Recurrent Acute Myelogenous Leukemia or Myelodysplastic Syndrome [J].
de Lima, Marcos ;
Giralt, Sergio ;
Thall, Peter F. ;
Silva, Leandro de Padua ;
Jones, Roy B. ;
Komanduri, Krishna ;
Braun, Thomas M. ;
Nguyen, Hoang Q. ;
Champlin, Richard ;
Garcia-Manero, Guillermo .
CANCER, 2010, 116 (23) :5420-5431
[3]   Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study [J].
Fenaux, Pierre ;
Mufti, Ghulam J. ;
Hellstrom-Lindberg, Eva ;
Santini, Valeria ;
Finelli, Carlo ;
Giagounidis, Aristoteles ;
Schoch, Robert ;
Gattermann, Norbert ;
Sanz, Guillermo ;
List, Alan ;
Gore, Steven D. ;
Seymour, John F. ;
Bennett, John M. ;
Byrd, John ;
Backstrom, Jay ;
Zimmerman, Linda ;
McKenzie, David ;
Beach, C. L. ;
Silverman, Lewis R. .
LANCET ONCOLOGY, 2009, 10 (03) :223-232
[4]   Induction of a CD8+ T-cell response to the MAGE cancer testis antigen by combined treatment with azacitidine and sodium valproate in patients with acute myeloid leukemia and myelodysplasia [J].
Goodyear, Oliver ;
Agathanggelou, Angelo ;
Novitzky-Basso, Igor ;
Siddique, Shamyla ;
McSkeane, Tina ;
Ryan, Gordon ;
Vyas, Paresh ;
Cavenagh, Jamie ;
Stankovic, Tanja ;
Moss, Paul ;
Craddock, Charles .
BLOOD, 2010, 116 (11) :1908-1918
[5]   Quantitative assessment of minimal residual disease in acute myeloid leukemia carrying nucleophosmin (NPM1) gene mutations [J].
Gorello, P. ;
Cazzaniga, G. ;
Alberti, F. ;
Dell'Oro, M. G. ;
Gottardi, E. ;
Specchia, G. ;
Roti, G. ;
Rosati, R. ;
Martelli, M. F. ;
Diverio, D. ;
Lo Coco, F. ;
Biondi, A. ;
Saglio, G. ;
Mecucci, C. ;
Falini, B. .
LEUKEMIA, 2006, 20 (06) :1103-1108
[6]   Assessment of minimal residual disease in acute myeloid leukemia [J].
Grimwade, David ;
Vyas, Paresh ;
Freeman, Sylvie .
CURRENT OPINION IN ONCOLOGY, 2010, 22 (06) :656-663
[7]   Towards individualized follow-up in adult acute myeloid leukemia in remission [J].
Hokland, Peter ;
Ommen, Hans Beier .
BLOOD, 2011, 117 (09) :2577-2584
[8]   Minimal residual disease levels assessed by NPM1 mutation-specific RQ-PCR provide important prognostic information in AML [J].
Schnittger, Susanne ;
Kern, Wolfgang ;
Tschulik, Claudia ;
Weiss, Tamara ;
Dicker, Frank ;
Falini, Brunangelo ;
Haferlach, Claudia ;
Haferlach, Torsten .
BLOOD, 2009, 114 (11) :2220-2231
[9]  
Shayegi N, 2011, BONE MARROW TRANSPLA
[10]   Successful treatment of molecular relapse in NPM1-positive AML using 5-azacytidine [J].
Wermke, M. ;
Thiede, C. ;
Kiani, A. ;
Ehninger, G. ;
Bornhaeuser, M. ;
Platzbecker, U. .
LEUKEMIA, 2010, 24 (01) :236-237