Manipulation of the Th1/Th2 balance in autoimmune disease

被引：161

作者：

Nicholson, LB

Kuchroo, VK

机构：

[1] BRIGHAM & WOMENS HOSP,CTR NEUROL DIS,BOSTON,MA 02115

[2] HARVARD UNIV,SCH MED,BOSTON,MA 02115

来源：

CURRENT OPINION IN IMMUNOLOGY | 1996年 / 8卷 / 06期

关键词：

D O I：

10.1016/S0952-7915(96)80013-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Many autoimmune diseases are caused by autopathogenic Th1 cells. Because in vitro Th1 and Th2 cells cross-regulate each other, it is likely that the induction of self-antigen-specific Th2 cells can prevent autoimmune disease. In the past year, investigators have further defined the role of Th1 and Th2 cytokines in the induction and regulation of autoimmunity. Furthermore, the role of MHC-antigen-T-cell avidity (strength of signal) in inducing such protective immune responses has been elucidated.

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收藏

页码：837 / 842

页数：6

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