Thiourea, triazole and thiadiazine compounds and their metal complexes as antifungal agents

被引：144

作者：

Rodríguez-Fernández, E

Manzano, JL

Benito, JJ

Hermosa, R

Monte, E

Criado, JJ

机构：

[1] Univ Salamanca, Dept Quim Inorgan, Fac Farm, Salamanca 37007, Spain

[2] Univ Salamanca, Ctr Hispano Luso Invest Agrarias, Dept Microbiol & Genet, Salamanca 37007, Spain

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 2005年 / 99卷 / 08期

关键词：

antifungal agents; metal complexes; spectroscopic techniques; thiourea derivatives; x-ray structures;

D O I：

10.1016/j.jinorgbio.2005.05.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Many currently available antifungal and antibacterial agents have undesirable toxic effects, and a wide spread use of these drugs has lead to rapid development of drug resistant strains which are the leading cause for treatment failure in both clinical and agricultural applications. The present article provides a synopsis of recent progress in investigations of new classes of antifungal compounds: disubstituted aliphatic and aromatic thioureas, triazole and thiazine compounds which act as ligands for transition metals. Antifungal effects of these compounds and selected metallic complexes versus representative plant pathogenic fungi are reviewed. (c) 2005 Elsevier Inc. All rights reserved.

引用

页码：1558 / 1572

页数：15

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