What's the point of the type III secretion system needle?

被引:105
作者
Blocker, Ariel J. [2 ]
Deane, Janet E. [1 ]
Veenendaal, Andreas K. J. [1 ]
Roversi, Pietro [1 ]
Hodgkinson, Julie L. [1 ]
Johnson, Steven [1 ]
Lea, Susan M. [1 ]
机构
[1] Univ Oxford, Sir William Dunn Sch Pathol, Oxford OX1 3RE, England
[2] Univ Bristol, Sch Med Sci, Dept Cellular & Mol Med, Bristol BS8 1TD, Avon, England
基金
英国医学研究理事会; 英国惠康基金;
关键词
flagella; structure;
D O I
10.1073/pnas.0708344105
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Recent work by several groups has significantly expanded our knowledge of the structure, regulation of assembly, and function of components of the extracellular portion of the type III secretion system (T3SS) of Gram-negative bacteria. This perspective presents a structure-informed analysis of functional data and discusses three nonmutually exclusive models of how a key aspect of T3SS biology, the sensing of host cells, may be performed.
引用
收藏
页码:6507 / 6513
页数:7
相关论文
共 65 条
[1]   Flagellin polymerisation control by a cytosolic export chaperone [J].
Auvray, F ;
Thomas, J ;
Fraser, GM ;
Hughes, C .
JOURNAL OF MOLECULAR BIOLOGY, 2001, 308 (02) :221-229
[2]   ANALYSIS OF THE V-ANTIGEN LCRGVH-YOPBD OPERON OF YERSINIA-PSEUDOTUBERCULOSIS - EVIDENCE FOR A REGULATORY ROLE OF LCRH AND LCRV [J].
BERGMAN, T ;
HAKANSSON, S ;
FORSBERG, A ;
NORLANDER, L ;
MACELLARO, A ;
BACKMAN, A ;
BOLIN, I ;
WOLFWATZ, H .
JOURNAL OF BACTERIOLOGY, 1991, 173 (05) :1607-1616
[3]   The tripartite type III secreton of Shigella flexneri inserts IpaB and IpaC into host membranes [J].
Blocker, A ;
Gounon, P ;
Larquet, E ;
Niebuhr, K ;
Cabiaux, V ;
Parsot, C ;
Sansonetti, P .
JOURNAL OF CELL BIOLOGY, 1999, 147 (03) :683-693
[4]   Type III secretion systems and bacterial flagella: Insights into their function from structural similarities [J].
Blocker, A ;
Komoriya, K ;
Aizawa, S .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (06) :3027-3030
[5]   Structure and composition of the Shigella flexneri 'needle complex', a part of its type III secreton [J].
Blocker, A ;
Jouihri, N ;
Larquet, E ;
Gounon, P ;
Ebel, F ;
Parsot, C ;
Sansonetti, P ;
Allaoui, A .
MOLECULAR MICROBIOLOGY, 2001, 39 (03) :652-663
[6]   Function and molecular architecture of the Yersinia injectisome tip complex [J].
Broz, Petr ;
Mueller, Catherine A. ;
Mueller, Shirley A. ;
Philippsen, Ansgar ;
Sorg, Isabel ;
Engel, Andreas ;
Cornelis, Guy R. .
MOLECULAR MICROBIOLOGY, 2007, 65 (05) :1311-1320
[7]   Weapons of mass retraction [J].
Burrows, LL .
MOLECULAR MICROBIOLOGY, 2005, 57 (04) :878-888
[8]   Helical packing of needles from functionally altered shigella type III secretion systems [J].
Cordes, FS ;
Daniell, S ;
Kenjale, R ;
Saurya, S ;
Picking, WL ;
Picking, WD ;
Booy, F ;
Lea, SM ;
Blocker, A .
JOURNAL OF MOLECULAR BIOLOGY, 2005, 354 (02) :206-211
[9]   Helical structure of the needle of the type III secretion system of Shigella flexneri [J].
Cordes, FS ;
Komoriya, K ;
Larquet, E ;
Yang, SX ;
Egelman, EH ;
Blocker, A ;
Lea, SM .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (19) :17103-17107
[10]   The type III secretion injectisome [J].
Cornelis, Guy R. .
NATURE REVIEWS MICROBIOLOGY, 2006, 4 (11) :811-825