Expression of IFITM1 in chronic myeloid leukemia patients

被引：37

作者：

Akyerli, CB

Beksac, M

Holko, M

Frevel, M

Dalva, K

Özbek, U

Soydan, E

Özcan, M

Özet, GL

Ilhan, O

Gürman, G

Akan, H

Williams, BRG

Özçelik, T

机构：

[1] Bilkent Univ, Dept Mol Biol & Genet, TR-06800 Ankara, Turkey

[2] Ankara Univ, Sch Med, Dept Hematol, TR-06100 Ankara, Turkey

[3] Cleveland Clin Fdn, Lerner Res Inst, Dept Canc Biol, Cleveland, OH 44195 USA

[4] Case Western Reserve Univ, Dept Genet, Cleveland, OH 44106 USA

[5] Istanbul Univ, Inst Expt Med, Dept Genet, TR-34280 Istanbul, Turkey

[6] Numune Hosp, Div Hematol, TR-06100 Ankara, Turkey

[7] Ayhan Sahenk Fdn, TR-80670 Istanbul, Turkey

来源：

LEUKEMIA RESEARCH | 2005年 / 29卷 / 03期

基金：

美国国家卫生研究院;

关键词：

chronic myeloid leukemia; IFITM1; RT-PCR; gene expression;

D O I：

10.1016/j.leukres.2004.07.007

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

We investigated the peripheral blood gene expression profile of interferon induced transmembrane protein 1 (IFITM1) in sixty chronic myeloid leukemia (CML) patients classified according to new prognostic score (NPS). IFITM1 is a component of a multimeric complex involved in the trunsduction of antiproliferative and cell adhesion signals. Expression level of IFITM1 was found significantly different between the high- and low-risk groups (P = 9.7976 x 10(-11)) by real-time reverse transcription polymerase chain reaction (RT-PCR). Higher IFITM1 expression correlated with improved survival (P = 0.01). These results indicate that IFITM1 expression profiling could be used for molecular classification of CML, which may also predict survival. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：283 / 286

页数：4

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