The antiviral antibiotic feglymycin:: First direct-methods solution of a 1000+equal-atom structure

被引：32

作者：

Bunkóczi, G

Vértesy, L

Sheldrick, GM

机构：

[1] Univ Gottingen, Lehrstuhl Strukturchem, D-37077 Gottingen, Germany

[2] Aventis Pharma Deutschland GMBH, D-65926 Frankfurt, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 09期

关键词：

antibiotics; peptides; structure elucidation; X-ray diffraction;

D O I：

10.1002/anie.200461933

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The double-helical structure adopted by the antiviral peptide feglymycin (see picture) is reminiscent of that of gramicidin, but feglymycin is more likely to function as an ion carrier than as a membrane channel. With more than 1000 unique atoms this is the largest equal-atom crystal structure solved by ab initio direct methods. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA Weinheim.

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页码：1340 / 1342

页数：3

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