Ketamine and rapidly acting antidepressants: Breaking the speed of sound or light?

被引：7

作者：

Berk, Michael ^{[1
,2
,3
,4
]}

Loo, Collen ^{[5
,6
]}

Davey, Christopher G. ^{[2
,3
]}

Harvey, Brian H. ^{[7
,8
]}

机构：

[1] Deakin Univ, IMPACT Strateg Res Ctr, Sch Med, Barwon Hlth, Geelong, Vic, Australia

[2] Natl Ctr Excellence Youth Mental Hlth, Ctr Youth Mental Hlth, Melbourne, Vic, Australia

[3] Univ Melbourne, Dept Psychiat, Melbourne, Vic, Australia

[4] Florey Inst Neurosci & Mental Hlth, Parkville, Vic, Australia

[5] Univ New South Wales Sydney, Sch Psychiat, Sydney, NSW, Australia

[6] Univ New South Wales Sydney, Black Dog Inst, Sydney, NSW, Australia

[7] North West Univ, Div Pharmacol, Sch Pharm, Potchefstroom, South Africa

[8] North West Univ, Ctr Excellence Pharmaceut Sci, Potchefstroom, South Africa

来源：

AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY | 2018年 / 52卷 / 11期

基金：

英国医学研究理事会; 澳大利亚国家健康与医学研究理事会; 新加坡国家研究基金会;

关键词：

Ketamine; antidepressant; depression; treatment; psychiatry; METHAMPHETAMINE EXPOSURE; DEPRESSION; DISCONTINUATION; INFLAMMATION; BIOMARKERS; STRESS;

D O I：

10.1177/0004867418783567

中图分类号：

R749 [精神病学];

学科分类号：

100204 [神经病学];

摘要：

There is an urgent need for rapidly acting antidepressants. Current therapies share a delayed onset of action, contrasting with drugs of abuse that have rapid psychotropic effects but cause tolerance and dependence. A key uncertainty is whether there is a finite speed limit imposed by the critical role of homeostatic adaptive mechanisms that underpin the efficacy and onset of available psychotropic agents and whether this is mutable with emerging agents with potential rapid onset, in particular ketamine.

引用

收藏

页码：1026 / 1029

页数：4

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