Microwave-assisted synthesis of some 3,5-arylated 2-pyrazolines

被引：73

作者：

Azarifar, D ^{[1
]}

Ghasemnejad, H ^{[1
]}

机构：

[1] Bu Ali Sina Univ, Fac Sci, Dept Chem, Hamadan 65174, Iran

来源：

MOLECULES | 2003年 / 8卷 / 08期

关键词：

microwave irradiation; chalcones; 3,5-arylated-2-pyrazolines; pyrazolines; heterocyclic synthesis;

D O I：

10.3390/80800642

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Condensation of 2-acetylnaphthalene with benzaldehydes under microwave irradiation affords chalcones which undergo facile and clean cyclizations with hydrazines RNHNH2 (R= H, Ph, Ac) to afford 3,5-arylated 2-pyrazolines in quantitative yields, also under microwave irradiation and in the presence of dry AcOH as cyclizing agent. The results obtained indicate that, unlike classical heating, microwave irradiation results in higher yields, shorter reaction times (2-12 min.) and cleaner reactions.

引用

页码：642 / 648

页数：7

共 33 条

[1] Reactions with hydrazonoyl halides.: 31.: Synthesis of some new pyrrolidino[3 4-c]pyrazolines, pyrazoles, and pyrazolo[3,4-d]pyridazines [J].