Fifty-year old samples of progesterone demonstrate the complex role of synthetic impurities in stabilizing a metastable polymorph

被引：29

作者：

Lancaster, Robert W. ^{[1
]}

Harris, Lisa D. ^{[1
]}

Pearson, David ^{[2
]}

机构：

[1] UCL, Dept Chem, London WC1H 0AJ, England

[2] Pharmorphix Ltd, Cambridge CB1 0WE, England

来源：

CRYSTENGCOMM | 2011年 / 13卷 / 06期

基金：

英国工程与自然科学研究理事会;

关键词：

CRYSTAL; ACID;

D O I：

10.1039/c0ce00858c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We describe a unique experiment whereby analysis of fifty-year old samples of progesterone shows that a metastable, 'disappearing' polymorph contains several impurities that are not found in the stable form.

引用

页码：1775 / 1777

页数：3

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