Halogenating enzymes in the biosynthesis of antibiotics

被引：9

作者：

Burd, VN

van Pee, KH

机构：

[1] Grodno State Univ, Grodno 230015, BELARUS

[2] Tech Univ Dresden, Inst Biochem, D-8027 Dresden, Germany

来源：

BIOCHEMISTRY-MOSCOW | 2003年 / 68卷 / 10期

关键词：

halogenase; pyrrolnitrin; pentachloropseudilin; pyoluteorin; pyrroindomycin; rebeccamycin; thienodolin; Pseudomonas; Actinoplanes; Kitasatasporia; Sacharothrix; Actinomadura; Streptomyces;

D O I：

10.1023/A:1026362729567

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Using blot hybridization, it has been shown that microorganisms producing halogen-containing antibiotics-Pseudomonas pyrrocinia, P. aureofaciens ACN, P. aureofaciens Pa1, P. fluorescens CHA0, Actinoplanes sp., Kitasatasporia sp., Sacharothrix aerocolonigenes, Actinomadura melliaura, and Streptomyces albogriseolus-contain the genes of the halogenating enzymes related to tryptophan-7-halogenase and monodechloroaminopyrrolnitrin halogenase from P.fluorescens BL 915.

引用

页码：1132 / 1135

页数：4

共 12 条

[1] Cloning, sequencing and disruption of a bromoperoxidase-catalase gene in Streptomyces venezuelae: Evidence that it is not required for chlorination in chloramphenicol biosynthesis [J].

Facey, SJ ;

Gross, F ;

Vining, LC ;

Yang, KQ ;

vanPee, KH .

MICROBIOLOGY-UK, 1996, 142 :657-665

[2]

GASSEN HG, 1999, GENTECHNISCHE METODE

[3]

GRIBBLE GW, 1994, ENVIRON SCI TECHNOL, V28, pA310, DOI 10.1021/es00056a712

[4] Four genes from Pseudomonas fluorescens that encode the biosynthesis of pyrrolnitrin [J].

Hammer, PE ;

Hill, DS ;

Lam, ST ;

VanPee, KH ;

Ligon, JM .

APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 1997, 63 (06) :2147-2154

[5] NADH-dependent halogenases are more likely to be involved in halometabolite biosynthesis than haloperoxidases [J].

Hohaus, K ;

Altmann, A ;

Burd, W ;

Fischer, I ;

Hammer, PE ;

Hill, DS ;

Ligon, JM ;

vanPee, KH .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1997, 36 (18) :2012-2013

[6]

Hopwood D.A., 1985, GENETIC MANIPULATION

[7] THIENODOLIN, A NEW PLANT GROWTH-REGULATING SUBSTANCE PRODUCED BY A STREPTOMYCETE STRAIN .1. TAXONOMY AND FERMENTATION OF THE PRODUCING STRAIN, AND THE ISOLATION AND CHARACTERIZATION OF THIENODOLIN [J].

KANBE, K ;

OKAMURA, M ;

HATTORI, S ;

NAGANAWA, H ;

HAMADA, M ;

OKAMI, Y ;

TAKEUCHI, T .

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 1993, 57 (04) :632-635

[8] The non-haem chloroperoxidase from Pseudomonas fluorescens and its relationship to pyrrolnitrin biosynthesis [J].

Kirner, S ;

Krauss, S ;

Sury, G ;

Lam, ST ;

Ligon, JM ;

vanPee, KH .

MICROBIOLOGY-UK, 1996, 142 :2129-2135

[9]

NEIDLEMANN SL, 1986, BIOHALOGENATION PRIN

[10]

SACHERER P, 1994, FEMS MICROBIOL LETT, V116, P155, DOI 10.1111/j.1574-6968.1994.tb06694.x

← 1 2 →